GLUT
Glucose transporter in myocyte stimulated by insulin is:
| A | GLUT 1 | |
| B | GLUT 2 | |
| C | GLUT 3 | |
| D | GLUT 4 |
Glucose transporter in myocyte stimulated by insulin is:
| A | GLUT 1 | |
| B | GLUT 2 | |
| C | GLUT 3 | |
| D | GLUT 4 |
GLUT 4 Ref. Harper 28/e p171; Ganong 23/e p320
GLUT 4 is the transporter in muscle and adipose tissue that is stimulated by insulin Glucose transporters have been discussed in May 10
After an overnight fasting, levels of glucose transporters are reduced in which of the following cell?
| A |
Brain cells |
|
| B |
Hepatocytes |
|
| C |
Adipocytes |
|
| D |
RBCS |
After an overnight fasting, levels of glucose transporters are reduced in which of the following cell?
| A |
Brain cells |
|
| B |
Hepatocytes |
|
| C |
Adipocytes |
|
| D |
RBCS |
Transport of glucose across a cell membrane occurs by facilitated diffusion. By this means of transport glucose is transported down the concentration gradient. This transport is accomplished by different isoforms of a super family of hydrophobic, integral membrane proteins referred to as glucose transporters.
Which of the following glucose transporter mediates insulin stimulated glucose uptake?
| A |
SGLT-1 |
|
| B |
GLUT-1 |
|
| C |
GLUT-2 |
|
| D |
GLUT 4 |
Which of the following glucose transporter mediates insulin stimulated glucose uptake?
| A |
SGLT-1 |
|
| B |
GLUT-1 |
|
| C |
GLUT-2 |
|
| D |
GLUT 4 |
Insulin stimulated glucose uptake into fat and muscle cells is mediated by GLUT 4. Insulin stimulates translocation of a pool of GLUT 4 to the plasma membrane through targeted exocytosis and depress the rate of GLUT4 endocytosis.
Which of the following type of glucose transporter is present in the skeletal muscle and adipose tissue?
| A |
GLUT 1 |
|
| B |
GLUT 2 |
|
| C |
GLUT 3 |
|
| D |
GLUT 4 |
Which of the following type of glucose transporter is present in the skeletal muscle and adipose tissue?
| A |
GLUT 1 |
|
| B |
GLUT 2 |
|
| C |
GLUT 3 |
|
| D |
GLUT 4 |
|
Tissue Location |
Functions |
|
|
GLUT 1 |
Brain, kidney, colon, placenta, erythrocytes |
Glucose uptake |
|
GLUT 2 |
Liver, pancreatic beta cell, small intestine, kidney |
Rapid uptake or release of glucose |
|
GLUT 3 |
Brain, kidney, placenta |
Glucose uptake |
|
GLUT 4 |
Heart and skeletal muscle, adipose tissue |
Insulin-stimulated glucose uptake |
|
GLUT 5 |
Small intestine |
Absorption of glucose |
Ref: Bender D.A., Mayes P.A. (2011). Chapter 20. Gluconeogenesis & the Control of Blood Glucose. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell (Eds), Harper’s Illustrated Biochemistry, 29e.
Which of the followoing is major site of Expression of GLUT5?
| A |
Renal tubules |
|
| B |
Brain |
|
| C |
Placenta |
|
| D |
Sperm |
Which of the followoing is major site of Expression of GLUT5?
| A |
Renal tubules |
|
| B |
Brain |
|
| C |
Placenta |
|
| D |
Sperm |
GLUT5 functions as Fructose transporter in sperm.
Adipocytes use which of following:
| A |
GLUT1 |
|
| B |
GLUT2 |
|
| C |
GLUT3 |
|
| D |
GLUT4 |
Adipocytes use which of following:
| A |
GLUT1 |
|
| B |
GLUT2 |
|
| C |
GLUT3 |
|
| D |
GLUT4 |
GLUT4 is expressed exclusively in adipocytes and skeletal and heart muscles, and translocation of GLUT4 from an intracellular pool to the plasma membrane is a major mechanism of the insulin-stimulated glucose uptake in these tissues adipocytes, and Chinese hamster ovary (CHO) cells expressing Gq-coupled bradykinin B2 receptors (BK2Rs).
The bradykinin-stimulated GLUT4 translocation may explain the exercise-induced glucose uptake in muscle cells.
Insulin resistance down-regulates –
| A |
GLUT-1 |
|
| B |
GLUT-2 |
|
| C |
GLUT-3 |
|
| D |
GLUT-4 |
Insulin resistance down-regulates –
| A |
GLUT-1 |
|
| B |
GLUT-2 |
|
| C |
GLUT-3 |
|
| D |
GLUT-4 |
Ans. is ‘d’ i.e., GLUT-4
Glucose diffusion in RBC by ‑
| A |
GLUT I |
|
| B |
GLUT 2 |
|
| C |
GLUT 3 |
|
| D |
GLUT 4 |
Glucose diffusion in RBC by ‑
| A |
GLUT I |
|
| B |
GLUT 2 |
|
| C |
GLUT 3 |
|
| D |
GLUT 4 |
Ans. is ‘a’ i.e., GLUT 1
Insulin secretion is decreased by ‑
| A |
Glucogen |
|
| B |
Gastrin |
|
| C |
Secretin |
|
| D |
Somatostatin |
Insulin secretion is decreased by ‑
| A |
Glucogen |
|
| B |
Gastrin |
|
| C |
Secretin |
|
| D |
Somatostatin |
Ans. is ‘d’ i.e., Somatostatin
Glucose transporter involved in insulin stimulated glucose transport is GLUT –
| A |
1 |
|
| B |
2 |
|
| C |
3 |
|
| D |
4 |
Glucose transporter involved in insulin stimulated glucose transport is GLUT –
| A |
1 |
|
| B |
2 |
|
| C |
3 |
|
| D |
4 |
Ans. is ‘d’ i.e., 4
Fructose uptake in small intestine is via ‑
| A |
GLUT – 1 |
|
| B |
GLUT – 2 |
|
| C |
GLUT – 4 |
|
| D |
GLUT – 5 |
Fructose uptake in small intestine is via ‑
| A |
GLUT – 1 |
|
| B |
GLUT – 2 |
|
| C |
GLUT – 4 |
|
| D |
GLUT – 5 |
