Granuloma Inguinale
The hard chancre is seen in:
| A |
Syphilis |
|
| B |
Chancroid |
|
| C |
LGV |
|
| D |
Granuloma inguinale |
The hard chancre is seen in:
| A |
Syphilis |
|
| B |
Chancroid |
|
| C |
LGV |
|
| D |
Granuloma inguinale |
The hard chancre /hunterian chancre/primary chancre in syphilis is a single, painless, indurated ulcer.
A 26 year male patient presented with a granulomatous penile ulcer. On Wright Giemsa staining, tiny organisms of 2 microns are seen engulfed by macrophages. What is the causative organism?
| A |
LGV |
|
| B |
Calymmatobacterium granulomatis |
|
| C |
Neisseria |
|
| D |
Staph aureus |
A 26 year male patient presented with a granulomatous penile ulcer. On Wright Giemsa staining, tiny organisms of 2 microns are seen engulfed by macrophages. What is the causative organism?
| A |
LGV |
|
| B |
Calymmatobacterium granulomatis |
|
| C |
Neisseria |
|
| D |
Staph aureus |
Calymmatobacterium granulomatis is a gram-negative rod that causes granuloma inguinale (also known as donovanosis), a sexually transmitted disease characterized by genital ulceration and soft tissue and bone destruction.
The diagnosis is made by visualizing the stained organisms (Donovan bodies) within large macrophages from the lesion.
Tetracycline is the treatment of choice for this disease, which is rare in the United States but endemic in many developing countries.
C. granulomatis is also known as Klebsiella granulomatis.
Ref: Levinson W. (2012). Chapter 27. Minor Bacterial Pathogens. In W. Levinson (Ed), Review of Medical Microbiology & Immunology, 12e.
A 25 year old male presents to the clinic with a lesion on his penis. On examination he was noted to have a beefy red ulcer on the glans which bled when touched. Smear taken from the ulcer showed gram-negative intracytoplasmic cysts filled with deeply staining bodies that had a safety-pin appearance. What is he most likely suffering from?
| A |
Syphilis |
|
| B |
HSV infection |
|
| C |
Chancroid |
|
| D |
Granuloma inguinale |
A 25 year old male presents to the clinic with a lesion on his penis. On examination he was noted to have a beefy red ulcer on the glans which bled when touched. Smear taken from the ulcer showed gram-negative intracytoplasmic cysts filled with deeply staining bodies that had a safety-pin appearance. What is he most likely suffering from?
| A |
Syphilis |
|
| B |
HSV infection |
|
| C |
Chancroid |
|
| D |
Granuloma inguinale |
In donovanosis-
| A |
Pseudolymphadenopathy |
|
| B |
Penicillin is used for treatment |
|
| C |
Painful ulcer |
|
| D |
Suppurative lymphadenopathy |
In donovanosis-
| A |
Pseudolymphadenopathy |
|
| B |
Penicillin is used for treatment |
|
| C |
Painful ulcer |
|
| D |
Suppurative lymphadenopathy |
Ans. is `a’ i.e., Pseudolymphadenopathy
Donovanosis
- Caused by Calymmatobacterium granulomatis.
- C. granulomatis is ‑
– Gram negative
– Encapsulated
– Nonmotile
– Intracellular
- It shares many morphologic and serologic characteristic (antigenic) and > 99% homology at the nucleotide level with Klebsiella.
- Clinical manifestations
– IP —) 1-4 weeks
– Begins as one or more subcutaneous nodules that erode through skin to produce clean, granulomatous, sharply defined, usually painless lesions.
– The genitalia are involved in 90% of cases.
– Genital swelling, particularly of labia, is common.
– In donovanosis, heaped-up granulomatous tissue may follow and via subcutaneous extension to inguinal area may form “pseudo-buboes”; however, the absence of true lymphadenopathy is the hallmark of this infection.
– Complications Pseudoelephantiasis, phimosis and paraphimosis.
- Diagnosis:
– The preferred diagnostic method involves demonstration of typical intracellular Donovan bodies within large mononuclear cells visualized in smears prepared from lesions or biopsy specimens.
– Stain used is wright – Giemsa
- Treatment:
– Azithromycin (DOC)
– Doxycycline (2′d choice)
– Chloramphenicol
Donovanosis/granuloma venerum is caused by
| A |
Calymatobacter granulomatis |
|
| B |
T. pertenue |
|
| C |
Chlamydia Trachomatis |
|
| D |
H. ducreyi |
Donovanosis/granuloma venerum is caused by
| A |
Calymatobacter granulomatis |
|
| B |
T. pertenue |
|
| C |
Chlamydia Trachomatis |
|
| D |
H. ducreyi |
A i.e. Calymatobacter granulomatis
Treatment of granuloma inguinale is-
| A |
Tetracycline |
|
| B |
Sulphanomide |
|
| C |
Streptomycin |
|
| D |
Pencillin |
Treatment of granuloma inguinale is-
| A |
Tetracycline |
|
| B |
Sulphanomide |
|
| C |
Streptomycin |
|
| D |
Pencillin |
A i.e. Tetracycline
Pseudo bubo is seen in ‑
| A |
Donovanosis |
|
| B |
LGV |
|
| C |
Chancroid |
|
| D |
Leprosy |
Pseudo bubo is seen in ‑
| A |
Donovanosis |
|
| B |
LGV |
|
| C |
Chancroid |
|
| D |
Leprosy |
Ans. is ‘a’ i.e., Donovanosis
Donovan bodies are seen in:
| A |
Granuloma inguinale |
|
| B |
LGV |
|
| C |
Syphilis |
|
| D |
Herpes genitalia4 |
Donovan bodies are seen in:
| A |
Granuloma inguinale |
|
| B |
LGV |
|
| C |
Syphilis |
|
| D |
Herpes genitalia4 |
Ans. is ‘a’ i.e., Granuloma inguinale
