Irreversible cell injury
Irreversible cell injury is indicated by –
| A |
Accumulation of calcium in mitochondria |
|
| B |
Myelin figures |
|
| C |
ATP depletion |
|
| D |
Shifting of ribosomes |
Irreversible cell injury is indicated by –
| A |
Accumulation of calcium in mitochondria |
|
| B |
Myelin figures |
|
| C |
ATP depletion |
|
| D |
Shifting of ribosomes |
Ans. is ‘a’ i.e., Accumulation of calcium in mitochondrion
Large, flocculant, amorphous densities in mitochondrial matrix develop due to increased Ca+2 influx. Note :
o Small (not large) phospholipid rich amorphous densities are found in reversible injury.
Irreversible cell injury –
| A |
Mitochondrial densities |
|
| B |
Cellular swelling |
|
| C |
Blebs |
|
| D |
None |
Irreversible cell injury –
| A |
Mitochondrial densities |
|
| B |
Cellular swelling |
|
| C |
Blebs |
|
| D |
None |
Ans. is ‘a’ i.e., Mitochondrial densities
o Large flocculent amorphous densities in mitochondria are seen in irreversible injury.
Which of the following is ultrastructural feature of irreversible cell injury?
September 2010
| A |
Formation of phagolysosomes |
|
| B |
Formation of amorphous densities in the mitochondrial matrix |
|
| C |
Formation of blebs in plasma membrane |
|
| D |
Detachment of ribosomes from rough |
Which of the following is ultrastructural feature of irreversible cell injury?
September 2010
| A |
Formation of phagolysosomes |
|
| B |
Formation of amorphous densities in the mitochondrial matrix |
|
| C |
Formation of blebs in plasma membrane |
|
| D |
Detachment of ribosomes from rough |
Ans. B: Formation of amorphous densities in the mitochondrial matrix
Irreversible cell injury
- After the initiation of irreversible death, the cell and its organelles start to disintegrate, leading to rupture of the cells.
- Gradually, the cytotoxic edema starts to resolve and interstitial edema develops as the cell membranes disintegrate and the intracellular components become extracellular.
- This results in increased Brownian water motion and marked reduction in diffusion restriction.
- The neuronal death result in reduction of its markers (NAA)
