Irreversible cell injury

Irreversible cell injury

Q. 1

Irreversible cell injury is indicated by –

 A

Accumulation of calcium in mitochondria

 B

Myelin figures

 C

ATP depletion

 D

Shifting of ribosomes

Q. 1

Irreversible cell injury is indicated by –

 A

Accumulation of calcium in mitochondria

 B

Myelin figures

 C

ATP depletion

 D

Shifting of ribosomes

Ans. A

Explanation:

Ans. is ‘a’ i.e., Accumulation of calcium in mitochondrion

Large, flocculant, amorphous densities in mitochondrial matrix develop due to increased Ca+2 influx. Note :

o Small (not large) phospholipid rich amorphous densities are found in reversible injury.


Q. 2

Irreversible cell injury –

 A

Mitochondrial densities

 B

Cellular swelling

 C

Blebs

 D

None

Q. 2

Irreversible cell injury –

 A

Mitochondrial densities

 B

Cellular swelling

 C

Blebs

 D

None

Ans. A

Explanation:

Ans. is ‘a’ i.e., Mitochondrial densities

o Large flocculent amorphous densities in mitochondria are seen in irreversible injury.


Q. 3

Which of the following is ultrastructural feature of irreversible cell injury?         

September 2010

 A

Formation of phagolysosomes

 B

Formation of amorphous densities in the mitochondrial matrix

 C

Formation of blebs in plasma membrane

 D

Detachment of ribosomes from rough

Q. 3

Which of the following is ultrastructural feature of irreversible cell injury?         

September 2010

 A

Formation of phagolysosomes

 B

Formation of amorphous densities in the mitochondrial matrix

 C

Formation of blebs in plasma membrane

 D

Detachment of ribosomes from rough

Ans. B

Explanation:

Ans. B: Formation of amorphous densities in the mitochondrial matrix

Irreversible cell injury

  • After the initiation of irreversible death, the cell and its organelles start to disintegrate, leading to rupture of the cells.
  • Gradually, the cytotoxic edema starts to resolve and interstitial edema develops as the cell membranes disintegrate and the intracellular components become extracellular.
  • This results in increased Brownian water motion and marked reduction in diffusion restriction.
  • The neuronal death result in reduction of its markers (NAA)

Quiz In Between



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