Methyl Alcohol Poisoning

Methyl Alcohol Poisoning

Q. 1

Mechanism of action of ethyl alcohol in methyl alcohol poisoning is:

 A

Saturate alkaline phosphatase

 B

Blocks formation of formaldehyde

 C

Inhibit Ca release

 D

All of the above

Q. 1

Mechanism of action of ethyl alcohol in methyl alcohol poisoning is:

 A

Saturate alkaline phosphatase

 B

Blocks formation of formaldehyde

 C

Inhibit Ca release

 D

All of the above

Ans. B

Explanation:

Ethanol is the antidote for methyl alcohol poisoning.
Methyl alcohol is oxidized to formaldehyde by the enzyme catalase.
This catalase can also oxidize ethyl alcohol to acetaldehyde.
In methyl alcohol poisoning, ethyl alcohol by competition for catalase, blocks the formation of formaldehyde and allows the less toxic methyl alcohol to be excreted unmetabolized.
 
Ref: The Essentials of Forensic Medicine and Toxicology by KS Narayan Reddy, 27th edition, Page 513.

Q. 2

Which of the following is not used in methyl alcohol poisoning :

 A

Gastric lavage

 B

Dialysis

 C

Ethyl alcohol

 D

High does of vitamin B12

Q. 2

Which of the following is not used in methyl alcohol poisoning :

 A

Gastric lavage

 B

Dialysis

 C

Ethyl alcohol

 D

High does of vitamin B12

Ans. D

Explanation:

D i.e. High dose vit B12


Q. 3

Best method of treatment of Methyl alcohol poisoning is :

 A

Calcium gluconate

 B

Ethyl alcohol

 C

Amphetamines

 D

1 % Ammonia

Q. 3

Best method of treatment of Methyl alcohol poisoning is :

 A

Calcium gluconate

 B

Ethyl alcohol

 C

Amphetamines

 D

1 % Ammonia

Ans. B

Explanation:

B i.e. Ethyl alcohol

Quiz In Between


Q. 4

In methyl alcohol poisoning there is CNS depression, cardiac depression and optic nerve atrophy. These effects are produced due to

 A

Formaldehyde and formic acid

 B

Acetaldehyde

 C

Pyridine

 D

Acetic acid

Q. 4

In methyl alcohol poisoning there is CNS depression, cardiac depression and optic nerve atrophy. These effects are produced due to

 A

Formaldehyde and formic acid

 B

Acetaldehyde

 C

Pyridine

 D

Acetic acid

Ans. A

Explanation:

Ans. is ‘a’ i.e., Formaldyhyde and formic acid

o Methyl alcohol (methanol) is metabolized to formaldehyde by alcohol dehydrogenase and then to formic acid by aldehyde dehydrogenase. These compounds are responsible for the toxicity. Formic acid can lead to coma and blindness also. Therefore, inhibitor of alcohol dehydrogenase, Femepizole is used for treatment of methanol over dose.


Q. 5

Not true about methyl alcohol poisoning:

AIIMS 13

 A

Effects are due to formic acid

 B

Fomepizole competitively inhibits aldehyde dehy­drogenase

 C

Metabolic acidosis

 D

Blindness

Q. 5

Not true about methyl alcohol poisoning:

AIIMS 13

 A

Effects are due to formic acid

 B

Fomepizole competitively inhibits aldehyde dehy­drogenase

 C

Metabolic acidosis

 D

Blindness

Ans. B

Explanation:

Ans. Fomepizole competitively inhibits aldehyde dehy­drogenase

Quiz In Between



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