Neisseria Meningitidis

Neisseria Meningitidis

Q. 1

Which of the following is TRUE regarding Neisseria meningitidis infection?

 A

It is the most common cause of meningitis in children

 B

All strains are uniformly sensitive to sulfonamides

 C

Vaccines are contraindicated in immunosuppressed

 D

In India serotype B is most common cause

Q. 1

Which of the following is TRUE regarding Neisseria meningitidis infection?

 A

It is the most common cause of meningitis in children

 B

All strains are uniformly sensitive to sulfonamides

 C

Vaccines are contraindicated in immunosuppressed

 D

In India serotype B is most common cause

Ans. A

Explanation:

For children >3 months old, the most common organisms are S. pneumoniae, Neisseria meningitidis, and Staphylococcus aureus, with a lower incidence of S. pneumoniae meningitis since routine vaccinations with the conjugate vaccine.

Penicillin has long been the treatment of choice for meningococcal infections and sulfonamides are used only for chemoprophylaxis because of resistance. Serogroup A epidemics have been largely confined to tropical countries. Both MCV4 and MPSV4 can be given to individuals who are immunosuppressed.
 
Ref: Ray C.G., Ryan K.J. (2010). Chapter 30. Neisseria. In C.G. Ray, K.J. Ryan (Eds), Sherris Medical Microbiology, 5e.

 

 


Q. 2

The most likely candidate responsible for the production of overwhelming septicemic shock complicating bacteremia with Neisseria meningitidis is:

 A

Capsular polysaccharide

 B

Pili

 C

Lipopolysaccharide and outer Membrane

 D

Low-molecular-weight outer membrane proteins

Q. 2

The most likely candidate responsible for the production of overwhelming septicemic shock complicating bacteremia with Neisseria meningitidis is:

 A

Capsular polysaccharide

 B

Pili

 C

Lipopolysaccharide and outer Membrane

 D

Low-molecular-weight outer membrane proteins

Ans. C

Explanation:

Neisseria meningitidis is a gram-negative pathogen that causes 20% of meningitis cases, the second most common cause of the disease.
Bacteremia produced by this organism (meningococcemia) is characterized by high fever, hemorrhagic rashes (petechiae) often culminating in disseminated intravascular coagulation, and circulatory collapse (Waterhouse-Friderichsen syndrome).

Meningitis is the most common complication of meningococcemia.

The endotoxin (lipopolysaccharide) associated with the outer membrane of the cell wall of this organism is responsible for these symptoms.
Capsular polysaccharides and outer membrane proteins are useful antigenic markers for the classification of this organism but do not contribute to the development of septicemic shock.
 
Ref: Ray C.G., Ryan K.J. (2010). Chapter 30. Neisseria. In C.G. Ray, K.J. Ryan (Eds),Sherris Medical Microbiology, 5e.

Q. 3

Vaccine is NOT available against which serotype of Neisseria meningitidis?

 A

A

 B

B

 C

C

 D

Y

Q. 3

Vaccine is NOT available against which serotype of Neisseria meningitidis?

 A

A

 B

B

 C

C

 D

Y

Ans. B

Explanation:

Bivalent (groups A and C) or tetravalent (against groups A, C, Y and W-135) vaccines are available for protection against meningococcal meningitis.

Ref: Park 21st edition, page 151.

Q. 4

Differentiating feature of Neisseria gonococcus from Neisseria meningitides is ?

 A

Lactose fermentation

 B

Maltose fermentation

 C

Mannitol fermentation

 D

Sucrose fermentation

Q. 4

Differentiating feature of Neisseria gonococcus from Neisseria meningitides is ?

 A

Lactose fermentation

 B

Maltose fermentation

 C

Mannitol fermentation

 D

Sucrose fermentation

Ans. B

Explanation:

Ans. is ‘b’ i.e., Maltose fermentation


Q. 5

Skin lesion in meningococcal meningitidis is due to‑

 A

Exotoxin

 B

Endotoxin

 C

Allergic reaction

 D

Direct vascular Damage

Q. 5

Skin lesion in meningococcal meningitidis is due to‑

 A

Exotoxin

 B

Endotoxin

 C

Allergic reaction

 D

Direct vascular Damage

Ans. B

Explanation:

Ans. is ‘b’ i.e., Endotoxin 

  • Fulminant meningococcemia (purpura fulminans or Waterhouse – Friderichsen syndrome) is the most rapidly lethal form of septic shock experienced by humans. It differs from most otherform ofseptic shock by the prominance of hemorrhagic skin lesions (petechiae, purpura) and the consistent development of DIC.
  • The pathogenic agent appears to be the endotoxin (LPS) released by autolysis. It is a proinflammatory molecule, that stimulates monocytes, neutrophils and endothelial cells to release cytokines like IL – 1, TNF- IF -land IL – 8. Remember —> Capsular polysacchoride is the major virulence factor for meningococci.

Q. 6

Meningitis with rash is seen in

 A

Neisseria meningitidis 

 B

H. influenzae 

 C

Strepto. agalactae

 D

Pneumococcus

Q. 6

Meningitis with rash is seen in

 A

Neisseria meningitidis 

 B

H. influenzae 

 C

Strepto. agalactae

 D

Pneumococcus

Ans. A

Explanation:

Ans. is ‘a’ i.e., Neisseria meningitidis 


Q. 7

Most common organism which can contaminates crowded army camps is ?

 A

Klebsiella

 B

E. coli

 C

Neisseria meningitidis

 D

Staphylococcus

Q. 7

Most common organism which can contaminates crowded army camps is ?

 A

Klebsiella

 B

E. coli

 C

Neisseria meningitidis

 D

Staphylococcus

Ans. C

Explanation:

Ans. is ‘c’ i.e., Neisseria meningitidis

  • Epidemics of Neisseria meningitidis usually occur in closed crowded conditions like jails or army camps.

Q. 8

Most common cause of acute pyogenic meningitis in adolescents and young adults:        

September 2003

 A

H. influenzae

 B

N. meningitidis

 C

Staph. aureus

 D

Group B streptococci

Q. 8

Most common cause of acute pyogenic meningitis in adolescents and young adults:        

September 2003

 A

H. influenzae

 B

N. meningitidis

 C

Staph. aureus

 D

Group B streptococci

Ans. B

Explanation:

Ans. B i.e. N. meningitidis

Acute pyogenic (bacterial) meningitidis

  • The micro-organism that cause acute pyogenic meningitis vary with the age of the affected individual.
  • In neonates, they include Escherichia coli and the group B streptococci
  • At the other extreme of life, Streptococcus pneumoniae and Listeria monocytogenes are more common.
  • Among adolescents and in young adults, Neisseria meningitides is the most common pathogen, with clusters of cases causing frequent public health concerns.

Q. 9

Organism which can penetrate normal cornea:

March 2013 (c)

 A

Mycobacterium tuberculosis

 B

Neisseria gonorrhoeae

 C

Neisseria meningitidis

 D

Mycobacterium leprae

Q. 9

Organism which can penetrate normal cornea:

March 2013 (c)

 A

Mycobacterium tuberculosis

 B

Neisseria gonorrhoeae

 C

Neisseria meningitidis

 D

Mycobacterium leprae

Ans. B

Explanation:

Ans. B i.e. Neisseria gonorrhoeae


Q. 10

Waterhouse-Friderichsen syndrome is seen in ‑

 A

Pneumococci

 B

N. Meningitidis

 C

Pseudomonas

 D

Yersinia

Q. 10

Waterhouse-Friderichsen syndrome is seen in ‑

 A

Pneumococci

 B

N. Meningitidis

 C

Pseudomonas

 D

Yersinia

Ans. B

Explanation:

Ans. is ‘b’ i.e., N. Meningitidis

Fulminant meningococcemia (purpura fulminans or Waterhouse – Friderichsen syndrome) is the most rapidly lethal form of septic shock experienced by humans. It differs from most other form of septic shock by the prominance of hemorrhagic skin lesions (petechiae, purpura) and the consistent development of DIC.



Leave a Reply

%d bloggers like this:
Malcare WordPress Security