OROTIC ACIDURIA- Pyrimidine disorder

Orotic aciduria

Q. 1

Orotic aciduria is due to deficiency of ‑

 A

Decarboxylase

 B

Tyrosinase

 C

Isomerase

 D

Homogentisate oxidase

Q. 1

Orotic aciduria is due to deficiency of ‑

 A

Decarboxylase

 B

Tyrosinase

 C

Isomerase

 D

Homogentisate oxidase

Ans. A

Explanation:

Ans. is ‘a’ i.e., Decarboxylase 

Metabolic disease

Enzyme deficient
Maple syrup urine disease  Branched chain ketoacid dehydrogenase 
Methyl-melonic aciduria  Methyl-malonyl CoA mutase (isomerase) 
Isovaleryl-CoA dehydrogenase 

Sweaty feet odor in body

Tyrosinemia I (Tyrosinosis) 

Fumarylacetoacetate hydroxylase

Tyrosinemia II

Tyrosine transaminase (Tyrosine aminotransferase) 

Neonatal tyrosinemia

Hydroxyphenyl pyruvate hydroxylase 

Albinism

Tyrosinase

Alkaptonuria

Homogentisate oxidase

Phenylketonuria

Phenylalanine hydroxylase

Orotic aciduria 

Homocystinuria

Lesh-Nyhan syndrome 

Cystinosis

OMP decarboxylase

Cystathionine synthatase

Complete deficiency of enzyme HGPRT 

Cystine reductase 


Q. 2

Orotic aciduria like picture can be produced by deficiency of –

 A

Vitamin B12

 B

Essential fatty acids

 C

Riboflavin

 D

None of the above

Q. 2

Orotic aciduria like picture can be produced by deficiency of –

 A

Vitamin B12

 B

Essential fatty acids

 C

Riboflavin

 D

None of the above

Ans. A

Explanation:

Deficiency of folate or vitamin B12 can cause hematological changes similar to hereditaty ototic aciduria”

Quiz In Between



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