Parvovirus

Parvovirus

B 19 is the causative agent of erythema infectiosum (fifth  disease). It  is  associated  with transient aplastic crisis in persons with hereditary hemolytic anemia. In adults, it is also associated with polyarthralgia.

Ans. is c i.e. Rh incompatibility

Ans. is ‘b’ i.e., Parvovirus B-19 

“The Parvovirus B-19 is difficult to grow. Virus isolation is not used to detect infection.” 

.  Herpes virus grows in a variety of primary and continuous cell cultures. 

. Adenoviruses grow in tissue cultures

Papoviruses can be grown in tissue cultures

Ans. is `a’ i.e., Erythema infectiosum

• Parvovirus causes erythema infectiosum (fifth disease).

Ans. is ‘d’ i.e. Arthopathy 

Parvovirus infection in adult commonly causes acute arthalgia and arthritis. The characteristic feature of Parvovirus arthritis is that it is peripheral involves wrist, hand and knees and arthritis resolves by three weeks and it is non­destructive. Sometimes it is associated with rash.

Ans. is. `a’ i.e., Hydrops fetalis, `b’ i.e., Aplastic anemia, ‘c’ i.e., Abortion 

.    Most of the Parvo-B₁₉ infections are asymptomatic.

.   Most common manifestation of symptomatic B 19 infections is erythema infectiosum also known as fifth disease or slapped cheek disease.

.   Parvo-B₁₉ infection during pregnancy can lead to hydrops fetalis and fetal loss.

.   Parvo-B₁₉ occasionaly causes hemophagocytic syndrome.

Ans. is `a’ i.e., <10% spread by transplacental route

.    Vertical (transplacental) transmission rates are estimated to be 30⁰/0 or higher.

.    Transmission is primarily by respiratory route and also through blood.

.    Parvovirus is a DNA virus.

.    Parvovirus affects erythroid progenitors.

Ans. is `a’ i.e., Roseola infantum 

Ans. is ‘d’ i.e., Parvovirus 

Parvovirus B-19 induces aplastic crisis in children with hemolytic anemias as in sickle cell disease

Ans. is ‘c’ i.e., Erythema infectiosum

Answer is A (Parvovirus)

Aplastic crisis is usually triggered by an acute parvovirus infection.

Ans. is `c’ i.e. Parvovirus

The condition shown in the picture above represents erythema infectiosum characterized by slapped check appearance seen, and is causd by parvovirus.

Ans. is ‘b’ i.e., Aplastic crisis

• Parvovirus B19 selectively infects erythroid precursors and is the most common aetiological agent that induces
• aplastic crisis in patients with hereditary spherocytosis (and other Hemolytic disorders).

Transient aplastic crisis

• Persons with decreased erythrocytes caused by conditions such as iron deficiency anemia, human immunodeficiency virus sickle cell disease, spherocytosis or thalassemia are at risk of transient aplastic crisis if infected with parvovirus B19.
• The virus causes a cessation of erythrocyte production.
• Parvovirus infection may be the first manifestation in HS.
• It begins with reticulocytosis and thrombocytosis

Ans:C.)Parvo Virus

Erythema infectiosum(Slapped Cheek Syndrome) is shown in the image.

ERYTHEMA INFECTIOSUM

• Erythema infectiosum or fifth disease is one of several possible manifestations of infection by parvovirus B19.
• The name “fifth disease” comes from its place on the standard list of rash-causing childhood diseases, which also includes measles (1st), scarlet fever (2nd), rubella (3rd), Dukes’ disease (4th, however is no longer widely accepted as distinct) and roseola (6th).
• Fifth disease starts with a low-grade fever, headache, rash, and cold-like symptoms, such as a runny or stuffy nose. These symptoms pass, then a few days later the rash appears. The bright red rash most commonly appears in the face, particularly the cheeks. This is a defining symptom of the infection in children (hence the name “slapped cheek disease”).
• Teenagers and adults may present with a self-limited arthritis.
• Transmission:
  • Fifth disease is transmitted primarily by respiratory secretions (saliva, mucus, etc.) but can also be spread by contact with infected blood. The incubation period (the time between the initial infection and the onset of symptoms) is usually between 4 and 21 days. Individuals with fifth disease are most infectious before the onset of symptoms.