RESPIRATORY REFLEXES
Not a stimulus for normal/resting ventilation?
A |
Stretch receptors |
|
B |
J receptors |
|
C |
PO2 |
|
D |
PCO2 |
Not a stimulus for normal/resting ventilation?
A |
Stretch receptors |
|
B |
J receptors |
|
C |
PO2 |
|
D |
PCO2 |
J receptor [Ref Ganong 23/e p632; Guyton 11/e p5217
Guyton writes- “A .few sensory nerve endings have been described in the alveolar walls in juxtaposition to the pulmonary capillaries—hence the name “J receptors”. They are stimulated especially when the pulmonary capillaries become engorged with blood or when pulmonary edema occurs in such conditions as congestive heart failure. Although the functional role of the J receptors is not clear, their excitation may give the person a.feeling of dyspnea.”
Ventilation is controlled by group of neurons located in medulla and pons (described in detail in q. no. 18 Nov 2009). This rhythmic neural control is regulated by alterations in arterial PO2, PCO2 and I-1+ ions concentration. These chemical controls are supplemented by a number of non-chemical influences (like Stretch receptors) The ultimate goal of respiration is to maintain proper concentration of oxygen, carbon dioxide, and hydrogen ions in the tissues.
Stimuli Affecting the Respiratory Center. |
|
Chemical control |
|
CO2 (via CSF and brain interstitial fluid 1-1+ concentration) |
|
02 Er |
(via carotid and aortic bodies) |
Non-chemical control |
|
Vagal afferents from receptors in the airways and lungs |
|
Afferents from the pons, hypothalamus, and limbic system |
|
Afferents from proprioceptors |
|
Afferents from baroreceptors: arterial. atrial, ventricular, pulmonary |
Stretch receptors: The stretch receptors are located in the walls of the bronchi and bronchioles throughout the lungs. They transmit signals through the vagi into the dorsal respiratory group of neurons when the lungs become overstretched. when the lungs become overly inflated, the stretch receptors activate an appropriate feedback response that “switches off’ the inspiratory ramp and thus stops further inspiration.This is called the Hering-Breuer inflation reflex.
(Note that Ganong writes that J receptors are also stimulated by hyperinflation of the lung)
About Head’s paradoxical reflex, which of the following fact is TRUE?
A |
It plays an important role in normal respiration |
|
B |
It is mediated by tracheobronchial-stretch receptors |
|
C |
It is stimulated by hyperinflation of lungs |
|
D |
It inhibits respiration |
About Head’s paradoxical reflex, which of the following fact is TRUE?
A |
It plays an important role in normal respiration |
|
B |
It is mediated by tracheobronchial-stretch receptors |
|
C |
It is stimulated by hyperinflation of lungs |
|
D |
It inhibits respiration |
Head’s paradoxical reflex:
- Inflation of lungs, under certain conditions, enhances inspiratory activity.
- Since inflation induces further inflation of lungs, the reflex is considered paradoxical.
- The vagal fibers mediating Head’s paradoxical reflex carry information originating in receptors present in lungs.
- This reflex has a role in initiation of respiration at birth.
Incorrect about Hering-Breuer inflation reflex is:
A |
Functions as a protective mechanism |
|
B |
Involves pulmonary stretch receptors |
|
C |
Involves inhibition of the inspiratory center |
|
D |
Protects against under inflation of the lungs |
Incorrect about Hering-Breuer inflation reflex is:
A |
Functions as a protective mechanism |
|
B |
Involves pulmonary stretch receptors |
|
C |
Involves inhibition of the inspiratory center |
|
D |
Protects against under inflation of the lungs |
Hering-Breuer inflation reflex: Inflation of the lungs stimulates stretch receptors of the alveoli and bronchial branchings (slow adapting), which in turn inhibit inspiration and consequently stimulate expiration through vagi. Seen only in new borns. The inflation reflex prevents overexpansion of the lungs thus it is a protective mechanism.
“Inflation of lungs induces further inflation” is explained by:
A |
Hering-Breuer inflation reflex |
|
B |
Hering-Breuer deflation reflex |
|
C |
Head’s paradoxical reflex |
|
D |
J-reflex |
“Inflation of lungs induces further inflation” is explained by:
A |
Hering-Breuer inflation reflex |
|
B |
Hering-Breuer deflation reflex |
|
C |
Head’s paradoxical reflex |
|
D |
J-reflex |
C i.e Head’s paradoxical reflex.
- Inflation of lungs, under certain conditions, enhances inspiratory activity.
- Since inflation induces further inflation of lungs, the reflex is considered paradoxical.
- The vagal fibers mediating Head’s paradoxical reflex carry information originating in receptors present in lungs.
- This reflex has a role in the initiation of respiration at birth.