Serotonin And Noradrenaline Reuptake Inhibitors (SNRI)

SEROTONIN AND NORADRENALINE REUPTAKE INHIBITORS (SNRI)

Q. 1

All of the following agents are used in the treatment of hot flashes, EXCEPT:

 A

Tamoxifen

 B

Venlafaxine

 C

Gabapentin

 D

Paroxetine

Q. 1

All of the following agents are used in the treatment of hot flashes, EXCEPT:

 A

Tamoxifen

 B

Venlafaxine

 C

Gabapentin

 D

Paroxetine

Ans. A

Explanation:

Tamoxifen is a selective estrogen receptor modulator (SERM) which exhibits anti-estrogenic activity on tissues like breast and central nervous system and estrogenic activity on tissues like bone.

Tamoxifen produces hot flashes and other adverse effects, including cataracts and nausea

. The other three options – Venlafaxine, Gabapentin and Paroxetine are included in the non-hormonal treatment of hot flashes.

Ref: Levin E.R., Hammes S.R. (2011). Chapter 40. Estrogens and Progestins. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12e ; Treatment of the postmenopausal woman: By Rogerio A. Lobo, Pages 3-6.


Q. 2

Which is not a serotonin-norepinephrine reuptake inhibitor

 A

Paroxetine

 B

Mirtazapine

 C

None

 D

Venlafaxine

Q. 2

Which is not a serotonin-norepinephrine reuptake inhibitor

 A

Paroxetine

 B

Mirtazapine

 C

None

 D

Venlafaxine

Ans. A

Explanation:

A i.e Paroxetine 


Q. 3

Which of the following is a selective serotonin & nor epinephrine reuptake inhibitor ‑

 A

Fluoxetine

 B

Venlafaxine

 C

Sertaline

 D

Arnoxipine

Q. 3

Which of the following is a selective serotonin & nor epinephrine reuptake inhibitor ‑

 A

Fluoxetine

 B

Venlafaxine

 C

Sertaline

 D

Arnoxipine

Ans. B

Explanation:

Ans. is ‘b’ i.e., Venlafaxine

o Important SNRIs are :- Venalafaxine, Milnacipram, desvenalafaxine, Duloxetine.

Quiz In Between


Q. 4

Which of the following drugs is used for painful diabetic neuropathy

 A

Duloxetine

 B

Pregabalin

 C

Amitriptyline

 D

All of the above

Q. 4

Which of the following drugs is used for painful diabetic neuropathy

 A

Duloxetine

 B

Pregabalin

 C

Amitriptyline

 D

All of the above

Ans. D

Explanation:

Answer is D (All of the above):

Amitriptyline may all be used for treatment of painful diabetic neuropathy.

Two agents, Duloxetine and Pregabalin have been approved by the U.S. FDA for pain associated with diabetic neuropathy –


Q. 5

First line drug used for painful diabetic neuropathy is?

 A

Carbamazepine

 B

Duloxetine

 C

Venlafaxine

 D

EMLA

Q. 5

First line drug used for painful diabetic neuropathy is?

 A

Carbamazepine

 B

Duloxetine

 C

Venlafaxine

 D

EMLA

Ans. B

Explanation:

Answer is B (Duloxetine):

Duloxetine is often recommended as the agent of choice for first line therapy in Painful Diabetic Neuropathy. Pregabalin may also be used as the agent of choice for first line therapy but initiation of treatment is often preferred with Duloxetine (based on cost-effectiveness rather than efficacy). Tricyclic antidepressants may also be used as first line agents but are not FDA Approved.* this indication.

Currently, only duloxetine and pregabalin have FDA approval for management of diabetic neuropathy pain.


Q. 6

Which of the following is an atypical antidepressant‑

 A

Citalopram

 B

Sertaline

 C

Venlafaxine

 D

Reboxetin

Q. 6

Which of the following is an atypical antidepressant‑

 A

Citalopram

 B

Sertaline

 C

Venlafaxine

 D

Reboxetin

Ans. C

Explanation:

Ans. is ‘c’ i.e., Venlafaxine

Antidepressants

A. Typical

  • Tricyclic antidepressants
  1. NA + 5HT reuptake inhibitors :- Imipramine, Trimipramine, Amitriptyline, Clomipramine.
  2. Predominantly NA reuptake inhibitors :- Desipramine, Nortriptyline, Amoxapine, Reboxetine.
  • Selective serotonin reuptake inhibitors :- Fluoxetine, Paroxetine, Sertaline, Citalopram, Scitalopram.

B. Atypical :- Trazodone, Mianserine, Mitrazapine, Venalafaxin, Duloxetine, Tianeptine, Amineptine, Bupropion.

c. MAO inhibitors :- Tranylcypramine, Meclobemide, Clorgyline.

Quiz In Between



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