Rapoport- Leubering Cycle

In this cycle, 1,3 – BPG is converted into 2, 3 –BPG by an enzyme biphosphoglycerate mutase.
2,3- BPG is then converted into 3- phosphoglycerate by enzyme 2,3- biphosphoglycerate phosphatase.

Significance of Rapaport- Leubering Cycle-

The 2, 3 – BPG combines with haemoglobin and reduces the affinity towards oxygen. So, its presence has oxyhemoglobin unloads more oxygen to the tissues.
2,3BPG shifts the oxygen Dissociation curve to right.
If the glycolysis of RBCs is impaired there will be impaired synthesis of 2, 3 – BPG which causes left shift of O₂ dissociation curve and increase oxygen affinity of haemoglobin.
Under hypoxic, high altitude, fetal tissues, anaemic condition the 2, 3- BPG concentration in the RBC increases.

Rapoport Leubering cycle occurs in erythrocytes
2, 3 –bisphosphoglycerate combines with hemoglobin & reduces affinity towards oxygen.
2,3 BPG shifts the oxygen Dissociation curve to right due to reduced affinity towards oxygen
No ATP is generated (only one molecule generated through glycolysis in RBC utilized)
Under hypoxic conditions, 2, 3- BPG increases in RBCs
Cancer cells switching to glycolysis even in the presence of adequate O2 for oxidative phosphorylation c/d Warburg effect

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