Rapoport- Leubering Cycle

Rapoport- Leubering Cycle

  • Rapoport- Leubering Cycle occurs in RBCs (erythrocytes).

  • In this cycle, 1,3 – BPG is converted into 2, 3 –BPG by an enzyme biphosphoglycerate  mutase.
  • 2,3- BPG is then converted into 3- phosphoglycerate by enzyme 2,3- biphosphoglycerate phosphatase. 

Significance of Rapaport- Leubering Cycle-

  • The 2, 3 – BPG combines with haemoglobin and reduces the affinity towards oxygen. So, its presence has oxyhemoglobin unloads more oxygen to the tissues.
  • 2,3BPG shifts the oxygen Dissociation curve to right.
  • If the glycolysis of RBCs is impaired there will be impaired synthesis of 2, 3 – BPG  which causes left shift of O2  dissociation curve and increase oxygen affinity of haemoglobin.
  • Under hypoxic, high altitude, fetal tissues, anaemic condition the 2, 3- BPG concentration in the RBC increases.

Exam Important

  • Rapoport Leubering cycle occurs in erythrocytes
  • 2, 3 –bisphosphoglycerate combines with hemoglobin & reduces affinity towards oxygen.
  • 2,3 BPG shifts the oxygen Dissociation curve to right due to reduced affinity towards oxygen
  • No ATP is generated (only one molecule generated through glycolysis in RBC utilized)
  • Under hypoxic conditions, 2, 3- BPG increases in RBCs
  • Cancer cells switching to glycolysis even in the presence of adequate O2 for oxidative phosphorylation c/d Warburg effect
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