Regulation of fatty acid synthesis
REGULATION OF FATTY ACID SYNTHESIS
- The rate limiting step is Acetyl CoA carboxylase.
- Long Term Regulation- by regulation of gene expression
- Short Term Regulation-
- Allosteric regulation- allosteric activation of Acetyl CoA Carboxylase by Citrate
- Covalent modification- Acetyl CoA Carboxylase is active in dephosphorylated state and inactive in phosphorylated state.
| Activation of acetyl CoA Carboxylase | Inactivation of acetyl CoA carboxylase |
| Citrate | Acyl CoA |
| Insulin | Glucagon, Epinephrine |
| Dephosphorylation | Phosphorylation |
Elongation of Fatty Acid-
- It occurs in endoplasmic reticulum and in some mitochondria.
- By Fatty Acid Elongase system.
Synthesis of Unsaturated Fatty Acid–
- Occurs in endoplasmic reticulum.
- By enzyme Fatty Acyl CoA Desaturase.
Exam Important
- The rate limiting step is Acetyl CoA carboxylase.
- Short Term Regulation-
- Allosteric regulation- allosteric activation of Acetyl CoA Carboxylase by Citrate
- Covalent modification- Acetyl CoA Carboxylase is active in dephosphorylated state.
| Activation of acetyl CoA Carboxylase | Inactivation of acetyl CoA carboxylase |
| Citrate | Acyl CoA |
| Insulin | Glucagon, Epinephrine |
| Dephosphorylation | Phosphorylation |
- Elongation of Fatty Acid- It occurs in endoplasmic reticulum.
- Synthesis of Unsaturated Fatty Acid–
- Occurs in endoplasmic reticulum.
- By enzyme Fatty Acyl CoA Desaturase.
Don’t Forget to Solve all the previous Year Question asked on Regulation of fatty acid synthesis
Click Here to Start Quiz
Click Here to Start Quiz
