Regulation of fatty acid synthesis
| A | Malonyl CoA | |
| B | Acetyl CoA | |
| C | Citrate | |
| D | Biotin |
| A | Malonyl CoA | |
| B | Acetyl CoA | |
| C | Citrate | |
| D | Biotin |
Citrate
Which among the following is the allosteric activator of acetyl CoA carboxylase?
| A |
Malonyl CoA |
|
| B |
Acetyl CoA |
|
| C |
Citrate |
|
| D |
Biotin |
The first step in fatty acid synthesis involves:
| A |
Acetyl CoA carboxylase |
|
| B |
3-Hydroxyl CoA dehydrogenase |
|
| C |
Acetyl dehydrogenase |
|
| D |
Pyruvate kinase |
A i.e. Acetyle CoA Carboxylase
In which organelle (s) of hepatocyte, the elongation of long chain fatty acid takes place:
| A |
Endoplasmic reticulum (ER) |
|
| B |
Golgi body |
|
| C |
Mitochondria |
|
| D |
A and C both |
A & C i.e. ER and Mitochondria
Lipogenesis (i.e. the main pathway for denovo fatty acid synthesis) occurs in cytosolQ. Palmitate, a 16- carbon, fully saturated long chain fatty acid (16: 0) is the principal endproduct of fatty acid synthase system in animal cells. It is the precursor of other long chin fatty acid and may be elongated by addition of 2 carbon unit acetyl groups through the action of fatty acid elongation system present in smooth endo plasmic reticulum (SER) and mitochondriaQ. Mitochondrial FA chain elongation is not a common pathwayQ. It operates under anaerobic condPionsQ and is favoured by high NADH / NAD+ ratio and pyridoxal phosphate (coenzyme)Q.
Rate limiting enzyme in fatty acid synthesis ‑
| A |
PDH dehydrogenase |
|
| B |
Malonyl reductase |
|
| C |
Acetyl CoA carboxylase |
|
| D |
Transacetylase |
Ans. is ‘c’ i.e., Acetyl CoA carboxylase
