AChE inhibitors Q. 1 Which of the following is the most sensitive test for the diagnosis of myasthenia gravis? A Repetitive nerve stimulation test B Positive edrophonium test C Measurement of jitter by single fibre electromyography D Measurement of serum ACh-receptor binding antibodies Q. 1 Which of the following is the most sensitive test for […]
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ACETYLCHOLINESTERASE (AchE) INHIBITORS ACETYLCHOLINESTERASE (AchE) INHIBITORS/ANTI-CHOLINESTERASES Drugs inhibiting Anti-cholinesterase enzyme (Anti-ChE). Thereby, Protects Ach from hydrolysis potentiating cholinergic effects. Increases it’s availability. Prolongs acetylcholine (Ach) actions. DRUGS & CLASSIFICATION: Classified into reversible & irreversible grp. of drugs. Reversible: Do not covalently modify ACh’esterase. Carbamates: Physostigmine (t) Neostigmine (q) Pyridostigmine Edrophonium Rivastigmine Donepezil Acridine Tacrine Irreversible
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