Alkaptonuria Q. 1 Alkaptonuria is caused by defect in which of the following enzymes? A Enolase B Homogentisate oxidase C Pyruvate carboxylase D None of the above Q. 1 Alkaptonuria is caused by defect in which of the following enzymes? A Enolase B Homogentisate oxidase C Pyruvate carboxylase D None of the above Ans. B […]
ALKAPTONURIA Alkaptonuria (Black Urine Disease) It is due to deficiency of homogentisate oxidase. Inheritance- autosomal recessive disorder. It is a first inborn error detected It belongs to Gerrad’s Tetrad. Homogentisate accumulates in tissues and blood and is excreted into urine. Biochemical Defect- Homogentisic acid is oxidised by polyphenol oxidase to benzoquinone acetate then polymerized to
