Anti-Emetic Drugs

Anti-Emetic Drugs

ANTI-EMETIC DRUGS Q. 1 Which of the following 5HT3 receptor blockers has highest receptor affinity  A Ondansetron  B Granisetron  C Dolasetron  D Palonosetron Q. 1 Which of the following 5HT3 receptor blockers has highest receptor affinity  A Ondansetron  B Granisetron  C Dolasetron  D Palonosetron Ans. D Explanation: Palonosetron [Ref. Katzung Pharma 10th/e p 1027] 5 […]

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Anti-Emetic Drugs

ANTI-EMETIC DRUGS ANTI-EMETIC DRUGS Introduction: Physiology of vomiting (emesis): Step 1: Due to vomiting center (VC) stimulation in lateral medullary reticular formation. Step 2: Input received from GI mucosa, chemoreceptor trigger zone (CTZ) & vestibular apparatus. Step 3: GI mucosa irritation (by drugs/irritants) –> Releases serotonin –> Stimulating VC via 5HT3 receptors. CTZ – Rich

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