Cholesterol Synthesis

Cholesterol Synthesis

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Cholesterol synthesis Q. 1 The major step of regulation of cholesterol synthesis is:  A Cyclization of squalene to lanosterol  B 3-hydroxy-3-methylglutaryl-CoA synthase  C 3-hydroxy-3-methylglutaryl-CoA lyase  D 3-hydroxy-3-methylglutaryl-CoA reductase Q. 1 The major step of regulation of cholesterol synthesis is:  A Cyclization of squalene to lanosterol  B 3-hydroxy-3-methylglutaryl-CoA synthase  C 3-hydroxy-3-methylglutaryl-CoA lyase  D 3-hydroxy-3-methylglutaryl-CoA reductase Ans. […]

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Cholesterol Synthesis

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CHOLESTEROL SYNTHESIS CHOLESTEROL SYNTHESIS Cholesterol is the major sterol in humans. Major component in plasma membrane. Synthesis of Cholesterol Major sites- Liver, adrenal cortex, testis, ovaries and intestine. Cell organelle- endoplasmic reticulum and cytoplasm First material is Acetyl CoA. Acetyl- CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) Then HMG-CoA is converted to mevalonate by

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