Cotrimoxazole

Cotrimoxazole Fixed drug combination of Sulfamethoxazole and Trimethoprim MOA: INTRODUCTION Both bacteriostatic (Individually) Bactericidal – Combination  Both drugs have almost similar half-lives (10 Hrs) Maximum synergism for sensitive organism. Optimal synergism obtained at 5:1 dose ratio (e.g. 800 mg:160 mg) TMP crosses BBB and placenta  SMZ doesn’t cross. TMP – more rapidly absorbed than SMZ TMP – 45% plasma protein […]