Cyclosporin
Cyclosporin CYCLOSPORIN Type of immunosuppressant drug. Specific T-cell Inhibitor/ calcineurin Inhibitor. Acts on CD4 cells & lymphocytes. Major pharmacological effects: Selective inhibition: Antigen-stimulated activation & proliferation of T-cells (CD4 helper cells). Expression IL-2 & other cytokines by T cells. Affects inducer T-cells response to IL-1, without affecting suppressor T-cells. Mechanism of action: Binding protein – Cyclophilin. Inactivates calcineurin. Failure […]
