Fluoxetine
Fluoxetine FLUOXETINE First Selective Serotonin Reuptake Inhibitors (SSRI) drug introduced. Non-sedating antidepressant. Mode of action: Potent serotonin blocker. Inhibition of axonal uptake of 5HT by interacting with serotonin transporter (SERT). PHARMACOKINETICS: Bioavailability 60–80% Protein binding 94–95% Metabolism Liver (mostly CYP2D6-mediated) Biological half-life 1–3 days (acute) 4–6 days (chronic) Excretion Urine (80%), faeces (15%) USES: Major depressive disorder Obsessive-compulsive disorder (OCD). Used in […]
