Ketoconazole
Ketoconazole KETOCONAZOLE MOA: 2 types of action. Block both testicular & adrenal androgen biosynthesis, reducing circulating testosterone levels. Via 17α-hydroxylase & 17, 20-lyase inhibition, both involved in synthesis & degradation of steroids, including testosterone precursors. Used as treatment for androgen-dependent prostate cancer. Due to its efficacy in reducing systemic androgen levels. An androgen receptor antagonist. Competing with androgens […]
