Langerhan’c cell Histiocytosis

Langerhan’c cell Histiocytosis

LANGERHANS CELL HISTIOCYTOSIS (LCH) LANGERHANS CELL HISTIOCYTOSIS. Previously referred to as “Histiocytosis X”.  Before identifying “unknown X”; X refers to Langerhans, Langerhans cells are dendritic cells functioning as antigen presenting cells, present mostly in skin – epidermis. Unusual proliferation of immature dendritic cells called “Langerhans cell histiocytosis”. Considered neoplastic with oncogenetic mutations of BRAF. Pathological morphology: Proliferating Langerhans cells

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