Leukotriene Antagonist

Leukotriene Antagonist LEUKOTRIENE ANTAGONIST Are also referred as “Leukotriene Receptor Antagonists” (LTRA’s). Non-steroidal anti-inflammatory bronchoconstriction preventors.  Work by blocking inflammatory reactions in airways. MECHANISM OF ACTION: Two main approaches to block leukotrienes actions: Inhibition of 5-lipoxygenase pathway Drugs inhibiting 5-lipoxygenase enzyme will inhibit synthetic pathway of leukotriene metabolism MK-886 – Blocks 5-lipoxygenase activating protein (FLAP), inhibiting 5-lipoxygenase enzyme functioning & helps in treating atherosclerosis. Antagonism of cysteinyl-leukotriene […]