ORAL HYPOGLYCEMIC DRUGS Q. 1 A 75-yrs-old woman with diabetes is taking an oral antidiabetic drugs. One day she goes without eating for 18 h. Her serum glucose concentration is 48 mg/dL (hypoglycemic) upon arrival at the emergency department, where she is deemed to be in critical condition. Which of the following drugs most likely […]
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ORAL HYPOGLYCEMIC DRUGS ORAL HYPOGLYCEMIC DRUGS Drugs may be classified into 2 groups based on MOA. I) INSULIN SECRETAGOGUES: Secretes insulin. Hence, insulin secretagogues. Effective only if, 30% more of β-cells in pancreas. Drugs include sulfonylureas & meglitinides. Limitation – Causes hypoglycemia. MOA: These drugs acting by insulin release. Drugs inhibit ATP sensitive K+ channels à Depolarization
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