Pyrazinamide
Pyrazinamide PYRAZINAMIDE (Z) INTRODUCTION: Weakly bactericidal drug. Most effective against slowly replicating bacteria in acidic media. Acidic medium – Sites of inflammation & intracellular sites. Hence, potent sterilizing effect. Risk of relapse is reduced. Good CSF penetration. Half-life of prolonged during renal & hepatic impairment. MECHANISM OF ACTION: Pyrazinamide mycobacterial complex→Pyrazinamidase pncA→ Pyrazinoic acid→ Inhibits plasma membrane […]
