Sodium-Potassium Pump

Sodium-Potassium Pump SODIUM-POTASSIUM PUMP/Na2+-K+ ATPase/Na2+-K+ PUMP: Most important pump for primary active transport in body.  An Electrogenic pump. Responsible for maintaining Na2+ & K+ conc. difference across cell membrane. Mechanism: ICF – High K+ concentration. ECF – High Na2+ concentration. Both Na2+ & K+ transported against concentration gradient. Uses energy by hydrolyzing ATP; Pump contains ATPase activity. Na2+-K+ pump extrudes – 3 Na2+ out from cell. Pumps 2 K+ into cell. Coupling ratio of Na2+-K+pump – 3:2. Structure: Na2+-K+pump-Carrier protein – Heterodimer. Made of two separate globular proteins: Larger α-subunit –  Molecular weight -100,000 Smaller […]