STIMULANTS Q. 1 Effect of cocaine on blood vessels is? A Vasoconstrictor B Vasodilator C Vasoineffective D First constrict then dilates Q. 1 Effect of cocaine on blood vessels is? A Vasoconstrictor B Vasodilator C Vasoineffective D First constrict then dilates Ans. A Explanation: Vasoconstrictor REF: KDT 4th e p. 166 Effect of local anesthetic on […]
STIMULANTS STIMULANTS Introduction: Main substance included – Cocaine. Cocaine: Derived from “Erythroxylum coca”. Studied by Sigmund Freud. MOA: Acts primarily by blocking dopamine receptors (D1 & D2) –> increasing dopamine concentration in synaptic cleft. Inhibitor of norepinephrine uptake —> Significant sympathomimetic effect. Actions & Uses: Vasoconstriction: Marked vasoconstriction of peripheral arteries —> Hypertension. Vasoconstriction of epicardial coronary arteries
