TCA POISONING Q. 1 A women consumes several tablets of amitryptiline leading to poisoning. All of the following can be done except A Sodium bicarbonate infusion B Gastric lavage C Diazepam to control seizure D Atropine as antidote Q. 1 A women consumes several tablets of amitryptiline leading to poisoning. All of the following can […]
TCA POISONING TRICYCLIC ANTIDEPRESSANT POISONING (TCA POISONING) Features of TCA overdose: 1. Mainly cardiotoxicity: Mainly cardiac (ventricular) arrhythmias – Results in mortality. Due to inhibition of cardiac fast Na+ channels –> Leading to, slowing of phase 0 depolarization in His-Purkinje tissue & myocardium. Other cardiotoxic features: Conduction defects Hypotension ECG changes like QRS & QT prolongation.
