TREATMENT OF OSTEOPOROSIS Q. 1 Decreased vitamin 0 [PGI May 00] 5. A 48 years old female suffering from severe menorrhagia (DUB) underwent hysterectomy. She wishes to take hormone replacement therapy. Physical examination and breast are normal but X – ray shows osteoporosis. The treatment of choice is A Progesterone B Estrogen and progesterone C Estrogen […]
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TREATMENT OF OSTEOPOROSIS TREATMENT OF OSTEOPOROSIS A.) BISPHOSPHONATES: Used for osteoporosis treatment. MOA: Due to their inhibitory effect on osteoclast-mediated bone resorption. Two mechanisms – By accelerating osteoclastic apoptosis. By suppressing differentiation of osteoclast precursors to mature osteoclasts – By IL-6 inhibition. Reduces cholesterol synthesis via farnesyl pyrophosphate synthase inhibition, by bisphosphonates. Drugs: 1st generation
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