A. They are present at the ends of eukaryotic chromosome
B. Increased telomerase activity favors cancer
C. DNA dependent RNA polymerase
D. A and B
The ends of each chromosome contain structures called telomeres.
Telomeres consist of short TG-rich repeats.
Telomerase, a multisubunit RNA template containing complex related to viral RNA-dependent DNA polymerases (reverse transcriptases), is the enzyme responsible for telomere synthesis and thus for maintaining the length of the telomere.
Since telomere shortening has been associated with both malignant transformation (Chapter 56) and aging (Chapter 58), this enzyme has become an attractive 867 target for cancer chemotherapy and drug development.