Question
Typical appearance of Tumour cells and Macrophages on Histological section indicate
A. ALCL.
B. CLL.
C. Diffuse large B cell lymphoma.
D. Burkitts’lymphoma.
Show Answer
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Correct Answer » D
Explanation
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Ans: D. Burkitts’ lymphoma
Starry Sky appearance composed of Tumor cells and macrophages is seen in the image,which is seen in Burkitt’s Lymphoma.
- Burkitt lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center.
Starry Sky appearance:
- The tumor cells (medium-sized lymphoid cells ), which are large with minimal cytoplasm, are closely apposed to each other, forming a dark blue background (the “sky”).
- These cells have a very high turnover rate, so the macrophages that happen to be hanging around get stuffed with cellular debris..
- The “starry sky” appearance seen under low power is due to scattered tingible body-laden macrophages (macrophages containing dead apoptotic tumor cells).
