Question
A 17 year old woman notices that her urine becomes red after she is given sulfonamides for treatment of a urinary tract infection. Both urine and serum test positive for free hemoglobin, and the urine red cell count is 1.2 million/mm3. A peripheral blood smear showed normocytic and normochromic red cells and a few “these cells” Deficiency of which of the following substances is most likely responsible for these symptoms
A. Alpha-chain of haemoglobin.
B. Beta-chain of hemoglobin.
C. Glucose-6-phosphate dehydrogenase.
D. Glycoprotein IIb/IIIa.
Show Answer
|
Correct Answer » C
Explanation
|
|
Ans: C. Glucose-6-phosphate dehydrogenase.
The cells marked by an arrow in the image are Bite cells
Bite cells
- Bite Cell (also called Degmacyte)is an abnormally shaped red blood cell with one or more semicircular portions removed from the cell margin.
- These “bites” result due to splenic removal of Heinz bodies (denatured hemoglobin) by macrophages in the spleen.
- Glucose-6-phosphate dehydrogenase deficiency, in which uncontrolled oxidative stress causes hemoglobin to denature and form Heinz bodies, is a common disorder that leads to the formation of bite cells.
