Identify the structure as represented by a black arrow in the blood smear of a patient given below?
A. Pappenheimer Bodies.
B. Cabot rings.
C. Howell-Jolly Bodies.
D. Heinz Bodies.
Ans: A. Pappenheimer Bodies
- Pappenheimer bodies are abnormal granules of iron found inside red blood cells .
- Pappenheimer bodies are visible with a Wright and/or Giemsa stain. Confirmation of non-heme iron in the granules is made with a Perls’ Prussian blue stain
- They are a type of inclusion body formed by phagosomes that have engulfed excessive amounts of iron.
- They appear as dense, blue-purple granules within the red blood cell and there are usually only one or two, located in the cell periphery.
- They are seen in diseases such as sideroblastic anemia, hemolytic anemia, and sickle cell disease.
- These cells stain for iron with Prussian blue stain. This distinguishes them from basophilic stippling and Howell-Jolly bodies.