Question
The drug of choice for poisoning due to sting of arthropod animal shown in photograph below is?
A. Esmolol.
B. Adrenaline.
C. N-acetyl cysteine.
D. Prazosin.
Show Answer
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Correct Answer » D Explanation |
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Ans: D. Prazosin.
The drug of choice for poisoning due to sting of scorpion is prazosin which is an alpha-blocker.
Hypertension is constant at the beginning of systemic envenoming and sometimes has a severe cardiac and respiratory impact
- Among the vasodilators, the α1-adrenergic blockers, Prazosin is recommended for the treatment of scorpion envenoming, especially in India.It has no major contraindications.
- It is more effective than nifepidine which blocks calcium ion influx of smooth muscle cells in the arterioles and inhibits their contraction.
- Hydralazine inhibits release of calcium ions in the smooth muscle of the vascular wall. It has several disadvantages, including sympathetic stimulation which increases heart rate, with a risk of myocardial infarction.
- Captopril, a drug that inhibits the conversion of angiotensin has also been suggested.However, captopril inhibits degradation of bradykinin, which plays an important role in the development of acute pulmonary edema.
Depending upon the severity of Scorpion poisoning,the management may include:
- Immunotherapy: dose depending on antivenom titer
- Prazosin
- Midazolam
- Aspirin
