Question
This patient is suffering from thyrotoxicosis.When she looks up,following picture is seen.Identify this sign.

A. Von Graefe’s sign
B. Joffroy’s sign
C. Moebius sign
D. Dalrymple’s sign
Show Answer
Correct Answer » B Explanation |
![]() |
Ans:B. Joffroy’s sign
Eye signs in thyrotoxicosis
- Stellwag’s sign: staring look, absent of normal blinking, first sign to appear(mild hyperthyroidism)
- Von Graefe’s sign(Lid Lag sign): inability of upper eyelid to keep pace with the eyeball (mild)
- Joffroy’s sign: absence of wrinkling on forehead when the patient looks up(frowns)(moderate)
- Moebius sign: lack of convergence of eyeball(severe hyperthyroidism)
- Dalrymple’s sign: upper eyelid retraction, sclera visible
- Jellinek’s sign: increased pigmentation of eyelid margins
- Enroth sign: edema of eyelids and conjunctiva
- Rosenbach’s sign: tremor of closed eyelids
- Gifford’s sign: difficulty in everting upper eyelid in primary toxic thyroid. Differentiates exophthalmos from other causes
- Loewi’s sign: dilation of pupil with weak adrenaline solution
- Knie’s sign: unequal dilation of pupil
- Cowen’s sign: jerky papillary contraction to consensual light
- Kocher’s sign: when clinician places his hands on patient’s eyes and lifts it higher, patient’s upper eyelid springs up more quickly than eye brows
- Naffziger’s sign: with patient in sitting position and neck fully extended, protruded eyeball can be visualized when observed from behind
- Proptosis due to infiltration of retrobulbar tissues with fluid and round cells
- Weakness of extraocular muscles(particularly inferior oblique) results in diplopia
- The most common ocular motility defect is a unilateral elevator palsy caused by the involvement of inferior rectus; next common – failure of abduction due to involvement of medial rectus