A 12-year-old boy presents with enlargement of bilateral cervical lymph nodes for 2 years. A biopsy from the lymph node reveals the following picture. Which of the following is the correct set of diagnosis, etiology and the cell described?
A. Hodgkin’s lymphoma; Epstein Barr Virus and Reed Sternberg cells
B. Hodgkin’s lymphoma; Epstein Barr Virus and Embryo cell
C. Non-Hodgkin’s lymphoma; HIV and Giant B cell
D. Tuberculosis, Mycobacterium and Tiny granuloma
Ans: A. Hodgkin’s lymphoma; Epstein Barr Virus and Reed Sternberg cells
(Ref: Robbins 9/e p608, 8/e p617)
- Given slide demonstrates Reed-Sternberg cells typical of Hodgkin’s Lymphoma.
- EBV infection – Risk factor for Hodgkin’s Lymphoma.
Reed-Sternberg cells & variants – Identification:
Diagnostic Reed-Sternberg cells:
- Large cells (45 pm in diameter) with multiple nuclei or a single nucleus with multiple nuclear lobes, each with a large inclusion-like nucleolus about the size of a small lymphocyte (5 to 7 pm in diameter).