Cholecystokinin (Cck)
CHOLECYSTOKININ (CCK)/Cholecystokinin-Pancreozymin (CCK-PZ)
- Secreted by cells in upper intestinal mucosa
- I cells in small intestine (Duodenum, jejunum & ileum)
- Also in nerves in distal ileum & colon
- Neurons in brain & other parts of body.
Stimulus for secretion:
- Products of protein digestion i.e., amino acids & peptides
- Presence of long chain fatty acids (>10 carbon atoms) in duodenum.
- Not triglycerides.
- Digestible form of fat.
- Carbohydrates are ineffective
Mode of action:
- Acts through group IIC hormonal mechanism.
FUNCTIONS:
- Stimulates pancreatic acinar cell enzymes secretion.
- Causes contraction of gall bladder.
- Relaxation of sphincter of oddi.
- Secretion of enzyme-rich pancreatic juice.
- Potentiates action of secretin on pancreas.
- Inhibits gastric emptying
- Increases motility of small intestine & colon.
- Increases enterokinase secretion
- Produces satiety
- Mechanism for hunger suppression is thought to be a decrease in gastric emptying rate.
- Relaxes lower esophageal sphincter secretin
- Augments contraction of pyloric sphincter
- Prevents reflux of duodenal contents into stomach
- Exerts trophic effect on pancreases
- Stimulates both insulin & glucagon secretion.
Exam Question
CHOLECYSTOKININ (CCK)/Cholecystokinin-Pancreozymin (CCK-PZ)
- Secreted by I cells in small intestine (Duodenum, jejunum & ileum).
Stimulus for secretion:
- Products of protein digestion i.e., amino acids & peptides.
- Presence of long chain fatty acids (>10 carbon atoms) in duodenum.
- Acts through group IIC hormonal mechanism
FUNCTIONS:
- Stimulates pancreatic acinar cell enzymes secretion.
- Causes contraction of gall bladder.
- Relaxation of sphincter of oddi.
- Secretion of enzyme-rich pancreatic juice.
- Potentiates action of secretin on pancreas.
- Inhibits gastric emptying.
- Increases motility of small intestine & colon.
- Increases enterokinase secretion.
- Produces satiety.
- Augments contraction of pyloric sphincter.
- Prevents reflux of duodenal contents into stomach.
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