CHRONIC INFLAMMATION

• Chronic inflammation is the inflammation of prolonged duration with tissue destruction.

 Characteristics of Chronic inflammation-

1. Infiltration with mononuclear cells includes- macrophages (most important), lymphocytes and plasma cells.
2. Tissue destruction or necrosis- Hallmark of chronic inflammation by activated macrophages.
3. Repair- healing takes place by angiogenisis and fibrous collagen.

 Types of Chronic inflammation-

It is of 2 types-

1. Chronic non specific inflammation
2. Granulomatous inflammation

System effects of chronic inflammation-

1. Fever
2. Leucocytosis
3. ESR increased
4. Amyloidosis

Exam Important