TUMOR PROTEIN 53 (TP53) TUMOR PROTEIN 53/TP53 INTRODUCTION: One among “Tumor suppressor gene”. A Phosphoprotein, barely detectable in nucleus of normal cells. Also referred to as “Molecular policeman”/“Guardian angel of genome” Due to its protective role in cell cycle. Hallmarks of cancer. In non-stressed, healthy cells has short half-life~20 mins Due to its association with MDM2. MDM2 – Negative […]
CNS DEPRESSANTS: Barbiturate poisoning & Chloral hydrate Barbiturate poisoning It is mostly suicidal, sometimes accidental. Manifestations are due to excessive CNS depression. patient is flabby and comatose with shallow and failing respiration cyanosis. fall in BP and cardiovascular collapse. Renal shut down, pulmonary complications, bullous eruption (barbiturate blisters). Hypothermia , Finally there is coma. Individuals
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Phosphorus Poisioning PHOSPHORUS POISONING: Phosphorus is a protoplasmic poison affecting cellular oxidation and causing anoxic necorbiosis, classically affecting liver. It increases fat deposition and inhibits glycogen deposition in liver. It is used in fire works (Diwali poisoning) and as rat poison. Lethal dose is 60-120 mg. Earliar CuSO4 was used as an antidote for phosphorous poisoning.
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Vegetables, Cantharides and Scorpion Poisons VEGETABLE POISONS Abrus precatorius (Ratti) Abrus seeds are odourless, tasteless, oval (egg shaped), bright red coloured with a black spot at one pole. They contain abrin a toxalbumin as its active principle, which is similar to viper snake venom. Raw or cooked seeds, when swallowed are non-poisonous. But if extract
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Corrosives Poisoning: Magenstrasse Introduction corrosives Poisoning: Magenstrasse(the gastric cannal or furrow) It is a groove in the stomach along the lesser curvature that is the route food and liquids tend to take in moving toward the pylorus and that is a frequent site of peptic ulcer formation. Corrosives fix, destroy and erode the surface with
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Laws of poisoning The laws related to poisoning are : (A) The drugs and cosmetic act 1940: The main aim is to control quality, purity and strength of drugs. The act has been further amended by drugs (Amendment) act 1964to include ayurvedic and unani drugs. The label or container of medicine should display the formula
Hair: Examination, Importance, & difference between Human Hair Vs. Animal Hair Introduction: Hair Examination Importance Identification: Identification of individual which may be accused, mutilated body etc. Source: Source of origin, whether animal or human. Sexual offences: Rape and unnatural sexual offences. Crimes: Hair or fibers found at the scene on weapons or clothes helps in
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Seminal stains. Introduction. Sensabaugh in 1977 reported the event of isolation of p30 in human seminal fluid. It is a glycoprotein of prostate origin. Detection of seminal stains becomes important in cases of rape, attempted rape, sexual murders of female, kidnapping, sodomy, bestiality, adultery and indecent assault etc. Seminal stains are generally found on the
Thermal injuries: chemical, electric and Lightening burns. Introduction: Chemical burns:- Chemical burns are produced by corrosive acids and alkalis. Acids with a pH less than 2 precipitate proteins causing coagulation necrosis. Nitric acid gives a yellow-brown scab, sulphuric (vitriol) a black-brown scab, Hydrochloric acid (spirit of salt) a white to grey scab, and carbolic acid
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Hanging: Postmortem findings,Strangulation,Medico-legal aspects of hanging. Introduction Postmortem findings Ligature mark is above thyroid cartilage, inconplete, bitaterally symmetrial and directed obliquely upward extending to the angles of mandible, then to mastoid and finally to occipital protuberance. Ligature mark is an example of imprinted/pressure/patterned abrasion. There is dribbling of saliva from the angle of the mouth
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