Components Of Body Fluids

Components Of Body Fluids


COMPONENTS OF BODY FLUIDS

BODY FLUID COMPARTMENTS: 

Total Body Water (TBW) (60% of body weight) – 42 liters

Intracellular fluid(ICF)

Extracellular fluid (ECF)

40% body weight (28 litres)

33% Total body water & 20% body weight – 14 litres

Interstitial fluid 

Plasma

15% of body

weight (10.5 -15 litres)

5% of body weight (3.5 litres)

  •  An adult weighing 70 Kg contains 42 liters of water.
  • In early fetal life, TBW is 90% reduced to 75-80% at birth → Reducing further to 60% by end of one year.

COMPOSITION OF ECF & ICF:

ECF:Most abundant cation-Na+ (142 meq/l)

  • Most abundant anion- Cl- (103 meq/l)
  • Bicarbonate concentration HCO3 (28 meq/l)

ICF:

  • Most abundant cation – K+ (150 meq/l) & Mg2+ (58 meq/l)
  • Most abundant anion – Phosphates  (75 meq/l) > Proteins (40 meq/l).
  • Thus ECF to ICF ratio will have a high Na+: K+ ratio.
  • pH – Slightly lower than ECF and slightly alkaline in nature.

MEASUREMENT OF BODY FLUID COMPARTMENTS

  •  Measurement of body fluid volumes is done by ‘Dilution method’
VOLUME MEASUREMENT
TBW
  • By Heavy water (Deuterium oxide), Tritium oxide, Aminopyrine.
  • By dilution principle
ECF
  • By inulin (most accurate), Sucrose, Mannitol, radioactive sodium, radioactive iodide, Thiosulfate
PLASMA VOLUME(PV)
  • By using Evans blue (T1824), Serum albumin labeled with radioactive Iodine
RED CELL VOLUME
  • By RBCs tagged with radioactive Chromium -51, Phosphorus-32, Fe-55 or Fe59
ICF
  • Can’t be measured directly.
  • Formula = (TBW-ECF)

Exam Important

COMPONENTS OF BODY FLUIDS

Total Body Water (TBW) (60% of body weight) – 42 liters

Intracellular fluid(ICF)

Extracellular fluid (ECF)

40%

body weight (28 litres)

33% Total body water & 20% body weight – 14 litres

Interstitial fluid 

Plasma

15% of body weight (10.5 -15 liters)

5% of body weight (3.5 liters)

  • An adult weighing 70 Kg contains 42 liters of water.
  • In early fetal life, TBW is 90% reduced to 75-80% at birth → Reducing further to 60% by end of one year.

COMPOSITION OF ECF & ICF:

ECF:

  • Most abundant cation-Na+ (142 meq/l)
  • Most abundant anion- Cl- (103 meq/l)
  • Bicarbonate concentration HCO3 (28 meq/l)

ICF:

  • Most abundant cation – K+ (150 meq/l) & Mg2+ (58 meq/l)
  • Most abundant anion – Phosphates  (75 meq/l) > Proteins (40 meq/l).
  • pH – Slightly alkaline in nature.

MEASUREMENT OF BODY FLUID COMPARTMENTS

VOLUME MEASUREMENT
TBW By Heavy water (Deuterium oxide)   
ECF
  • By inulin (most accurate), Sucrose, radioactive sodium.
PLASMA VOLUME(PV)
  • By using Evans blue (T1824), Serum albumin labeled with radioactive Iodine
RED CELL VOLUME
  • By RBCs tagged with radioactive Chromium -51.
Don’t Forget to Solve all the previous Year Question asked on Components Of Body Fluids

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