Dapagliflozin
DAPAGLIFLOZIN
- An SGLT-2 inhibitor drug of gliflozin class.
- Used in type 2 diabetes treatment.
- Efficacy & safety yet to be proved.
MECHANISM OF ACTION:
- Glucose is reabsorbed completely in proximal tubules by sodium-glucose cotransporter-2 [SGLT-2].
- Dapagliflozin acts by inhibiting SGLT-2 transporter.
METABOLISM:
- Are effective orally.
Effects:
- Single daily dose produces continuous glucosuria lowering blood glucose levels.
SIDE EFFECTS:
Main effects:
- Heavy glycosuria (Up to 70 grams/day).
- Causes rapid weight loss & tiredness.
- Increased incidence of urinary tract infections & genital infections (candidiasis).
- Because increased urinary glucose worsens infections already associated with diabetes.
- Increased risk of diabetic ketoacidosis.
- Increased urinary frequency.
Other effects:
- Decreases bone mineral density → Increases risk of fractures.
- Higher rates of breast & bladder cancers reported.
- Hypotensive reactions.
Exam Question
DAPAGLIFLOZIN
- Dapagliflozin acts by inhibiting SGLT-2 transporter.
- Dapagliflozin is an SGLT-2 inhibitor drug.
- A single daily dose of dapagliflozin produces continuous glucosuria lowering blood glucose levels, thus results in rapid weight loss, tiredness & increased incidence of urinary tract infections & genital infections
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