Fatty Liver
FATTY LIVER
- Fatty liver is the excessive accumulation of fat i.e. triacylglycerol in the liver (25- 30%)
- Triglycerides is stored in the adipose tissue.
- Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder.
Causes of Fatty liver–
1. Overproduction of triacylglycerols- it is due to
- Starvation, diabetes mellitus
- High fat diet
- Alcoholism
2. Raised levels of plasma free fatty acids- (VLDL synthesis impaired)
- Block in apolipoprotein synthesis
- Block in the synthesis of lipoprotein from lipid and apolipoprotein
- Block in the synthesis of phospholipids that are found in the VLDL.
- Failure in the formation mechanism of lipoprotein itself from lipid and apoprotein.
- Orotic acid
- Lack of lipotropic factors (choline, betaine, methionine, lecithine and inositol, vitamin B12, Vitamin E)
- Lipotropic Factors- which prevents the accumulation of fat (triglycerides) in liver.
Alcoholic Fatty Liver-
- First stage of alcoholic liver disease –à cirrhosis (caused by alcoholism)
Exam Question
- Fatty liver is the excessive accumulation of fat i.e. triacylglycerol in the liver (25- 30%)
- Triglycerides is stored in the adipose tissue.
- Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder.
- Causes- Overproduction of triacylglycerols and Raised levels of plasma free fatty acids- (VLDL synthesis impaired)
- Lack of lipotropic factors (choline, betaine, methionine, lecithine and inositol, vitamin B12, Vitamin E)
- Lipotropic Factors- which prevents the accumulation of fat (triglycerides) in liver.
Don’t Forget to Solve all the previous Year Question asked on Fatty Liver
