Inhibitors Of Protein Synthesis
INHIBITORS OF PROTEIN SYNTHESIS
- Tetracyclins– inhibits the binding of aminoacyl tRNA to the ribosomal complex. It is reversible and bacteriostatic.
- Streptomycin– Inhibits initiation of protein synthesis. It is irreversible and bactericidal.
- Strcutural analog of tyrosinyl tRNA. Inhibits protein synthesis in eukaryotes and prokaryotes.
- Chloramphenicol– inhibits enzyme peptidyl transferase. It is reversible and bacteriostatic.
- Erythromycin and clindamycin– lt inhibits translocation by binding with 50S subunit of bacterial ribosome. It is reversible and bacteriostatic.
- Diptheria toxin– prevents translocation in eukaryotic protein synthesis by inactivating elongation factor eEF2.
- Ricin- From castor bean inactivates eukaryotic 28S ribosomal RNA.
- 30S inhibitors- streptomycin, gentamycin, amikacin and tetracyclines.
- 50S inhibitors- Chloramphenicol, clindamycin, erythromycin, lincomycin.
Exam Question
- Streptomycin is an irreversible and bactericidal.
- Aminoglycosides drugs include gentamicin, amikacin, neomycin, streptomycin.
- Tetracycline drugs include doxycycline, minocycline.
- Mechanism of action of tetracycline is binds to 30S ribosome subunit.
- Aminoglycosides is bactericidal.
- Chloramphenicol is administered orally and IV.
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