Sphingophospholipids

Sphingophospholipids


Sphingophospholipids

  • Contains sphingosine as alcohol (no glycerol)
  • Most important sphingophospholipid is sphingomyelin.
  • Ceramide= sphingosine + long chain fatty acid.
  • Sphingomyelin = Ceramide + Phosphoryl group + Nitrogenous base
  • Phosphorylcholine= phosphoric acid + Choline.
  • Sphingomyelin is one of the principal structural lipids of membrane in nervous tissue.
  • Role in signalling and apoptosis.
  • Sphingolipids are present in nerve cells and brain cells.
  • Sphingomyelinase Deficiency causes- Niemann- Pick disease (accumulation of sphingomyelinase in brain, liver and spleen)
Exam Question
 
  • Contains sphingosine as alcohol (no glycerol)
  • Most important sphingophospholipid is sphingomyelin.
  • Ceramide= sphingosine + long chain fatty acid.
  • Sphingomyelin = Ceramide + Phosphoryl group + Nitrogenous base
  • Phosphorylcholine= phosphoric acid + Choline.
  • Sphingomyelin is one of the principal structural lipids of membrane in nervous tissue.
  • Role in signalling and apoptosis.
  • Sphingolipids are present in nerve cells and brain cells.
  • Sphingomyelinase Deficiency causes- Niemann- Pick disease (accumulation of sphingomyelinase in brain, liver and spleen)
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