Intracellular accumulations

Intracellular accumulations


INTRACELLULAR ACCUMULATION  

Abnormal intracellular accumulations takes place in 3 ways-

  1. Accumulation of normal constituents of cell metabolism in excess (lipid etc)
  2. Accumulation of abnormal substances
  3. Accumulation of pigments

1. Fatty change (Steatosis)

  • Abnormal accumulation of triglycerides within parenchymal cells is fatty change (steatosis).
  • Seen in liver (most common), heart, skeletal muscle, and kidney.
  • Alcohol abuse and diabetes associated with obesity are the most common causes of fatty change in the liver.
  • Cholesterol deposits- fibro fatty plaques of artherosclerosis.

2. Protein-

  • Disorder associated with misfolded/ unfolded proteins are alzeheimer’s disease, Huntington disease and parkinson’s disease.

3. Water

  • Intracellular water accumulations are known as cloudy swelling.

4. Pigments-

  • Two types- endogenous & exogenous

1. Exogenous-

  • Most common exogenous pigment is carbon.

2. Endogenous-

a) Lipofuschin-

  • Also known as wear and tear pigment/ aging pigment.
  • It is perinuclear brown pigment.
  • Seen in aging, severe malnutrition and cancer cachexia.

b) Melanin-

  • Detected by Fontana masson staining.
  • Synthesized by melanocytes.

c) Hemosiderin-

  • It is haemoglobin derieved pigment.
  • Detected by Perl’s Prussian blue staining.
  • Color of hemosiderin is brown.  

Exam Important

1. Fatty change (Steatosis)

  • Abnormal accumulation of triglycerides within parenchymal cells is fatty change (steatosis).
  • Seen in liver (most common), heart, skeletal muscle, and kidney.

2. Protein-

  • Disorder associated with misfolded/ unfolded proteins are alzeheimer’s disease, Huntington disease and parkinson’s disease.

3. Water

  • Intracellular water accumulations are known as cloudy swelling.

4. Pigment

a) Lipofuschin-

  • Also known as wear and tear pigment/ aging pigment.
  • It is perinuclear brown pigment.

b) Melanin-

  • Detected by Fontana masson staining.

c) Hemosiderin-

  • Detected by Perl’s Prussian blue staining.
  • Color of hemosiderin is brown
Don’t Forget to Solve all the previous Year Question asked on Intracellular accumulations

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