Iron Deficiency

Iron Deficiency


IRON DEFICIENCY ANEMIA

  • Iron deficiency can be divided into 3 stages-
  1. Negative iron balance
  2. Iron deficient erythropoiesis
  3. Iron deficiency anemia- microcytic hypochromic anemia

Causes of Iron Deficiency Anemia-

  • Increased demand for iron- pregnancy, erythropoietin therapy, growth period.
  • Increased Iron loss- acute & chronic blood loss, phlebotomy
  • Decreased iron absorption- diet, malabsorption of iron, surgery or gastrectomy.

 Lab diagnosis-

  • Decreased serum ferritin
  • Total iron binding capacity increased.
  • Iron deficiency can be indicated by MCHC.
  • Test to detect iron deficiency is serum ferritin.
  • Mentzer index more than 13 suggests a diagnosis of iron deficiency anemia.

Clinical features-

  • Fatigue, pallor
  • Chielosis
  • Koilonychias

Treatment

  • Red cell transfusion
  • Oral iron therapy- 200mg per day (100- 150 mg per day)
  • Parenteral iron therapy– iv iron,
    • Total parenteral iron requirement can be calculated by : 4.3 x Body weight (kg) x Hb deficit (g/dl)
    • Ferumoxytol delivers 510 mg of iron per injection, ferric gluconate 125mg per injection, ferric carboxymaltose 750 mg per injection, and iron sucrose 200 mg per injection.
  • Iron dextran (highest risk of anaphylaxis).

Exam Important

  1. Iron deficiency anemia- microcytic hypochromic anemia
  2. Causes- Decreased iron absorption- diet, malabsorption of iron, surgery or gastrectomy.
  3. Lab diagnosis-
  • Decreased serum ferritin
  • Total iron binding capacity increased.
  • Iron deficiency can be indicated by MCHC.
  • Test to detect iron deficiency is serum ferritin.
  • Mentzer index more than 13 suggests a diagnosis of iron deficiency anemia.

Treatment

  • Red cell transfusion
  • Oral iron therapy- 200mg per day (100- 150 mg per day)
  • Parenteral iron therapy– iv iron,
    • Total parenteral iron requirement can be calculated by : 4.3 x Body weight (kg) x Hb deficit (g/dl)
    • Ferumoxytol delivers 510 mg of iron per injection, ferric gluconate 125 mg per injection, ferric carboxymaltose 750 mg per injection, and iron sucrose 200 mg per injection.
  • Iron dextran (highest risk of anaphylaxis).
Don’t Forget to Solve all the previous Year Question asked on Iron Deficiency

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