Lathyrism

Lathyrism


Lathyrism

  • Neurolathyrism (NL) is a neurodegenerative disease that is caused by heavy consumption of grass pea, Lathyrussativus.

Toxin

  • The pulse contains the neurotoxin called b-N-oxalyl-a,b-diaminopropionic acid (b-ODAP).[Synonym b-oxalylaminoalanine(BOAA)]

History

  • Ancient disease.
  • Often occurs in epidemics.
  • Several epidemics occurred in most parts of the world

.Prevalance

  • India 5.3 per 1000

Onset

  • Depending on the amount of the pulse consumed and the susceptibility of the patients the paralysis can start as early as 3 weeks of consumption.
  • Paralysis can develop acutely overnight or progressively over days.
  • Mostly 3-6 months.
  • Acute or chronic.
  • Dose dependent.
  • Critical level = 400gm/day

Risk Factors

  • Heavy physical activity
  • Male gender
  • Young age (15-25 years)
  • Micronutrient deficiency (Zn, Cu, Vit C, Vit A) 

Clinical features

  • Upper motor neuron disorder with symmetrical spastic paralysis.
  • Sensation and sphincters are spared.

Stages of disease

  1. Stage II(No stick stage): spastic gait with no need to use a walking stick and no Babinski sign.
  2. Stage II( 1 stick stage): spastic gait with the need of one walking stick. Ankle clonus and Babinski sign present.
  3. Stage III( 2 stock stage): Spastic cross adductor gait with the need of two walking sticks. Ankle clonus and Babinsi sign present.
  4. Stage IV(Crawler stage): There is bedridden (wheelchair) state with loss of leg use and contracture. Arms are strong and pyramidal signs present.

Treatment

  • No definitive treatment.
  • The neuronal damages are permanent.
  • Symptomatic treatment with muscle relaxants help.

Prevention

  • Home-based detoxifying methods.
  • New seed lines.
  • Cultivation of alternate crops.
Exam Question
 

Lathyrism

  • Neurolathyrism (NL) is a neurodegenerative disease that is caused by heavy consumption of grass pea, Lathyrussativus.

Toxin

  • The pulse contains the neurotoxin called b-N-oxalyl-a,b-diaminopropionic acid (b-ODAP).[Synonym b-oxalylaminoalanine(BOAA)
Don’t Forget to Solve all the previous Year Question asked on Lathyrism

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