Lipoprotein Structure

Lipoprotein Structure


LIPOPROTEINS

  • Free fatty acids (FAA) is metabolically most active of the plasma lipids.
  • Lipids are transported in the form of lipoproteins.
  • Non polar lipid contains cholesterol ester, cholesterol, phospholipid, triacylglycerol.
  • Protein part of lipoprotein is apolipoprotein.

Major lipoproteins according to density are-

  1. Chylomicrons- These are principal form in which dietary lipids (exogenous lipids) are carried from intestine to liver.
  2. Very low density lipoproteins (VLDL)
  3. Low density lipoproteins (LDL)- major source of cholesterol to peripheral tissues.
  4. Intermediate density lipoproteins (IDL)
  5. High density lipoproteins (HDL)

Separation of Lipoproteins-

  1. Electrophoresis-
  • Chylomicrons have no mobility and remains at orginial position
  • HDL has maximum mobility and move longest distance.

2. Ultracentrifugation-

  • Chylomicrons are largest with maximum lipid contents.

Exam Important

  • Free fatty acids (FAA) is metabolically most active of the plasma lipids.
  • Non polar lipid contains cholesterol ester, cholesterol, phospholipid, triacylglycerol.
  • Protein part of lipoprotein is apolipoprotein.
  • Chylomicrons- These are principal form in which dietary lipids (exogenous lipids) are carried from intestine to liver.
  • Low density lipoproteins (LDL)- major source of cholesterol to peripheral tissues.

Electrophoresis-

  • Chylomicrons have no mobility and remains at orginial position
  • HDL has maximum mobility and move longest distance.

Ultracentrifugation-

  • Chylomicrons are largest with maximum lipid contents.
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