Metabolism of Chylomicron
LIPOPROTEIN METABOLISM
Chylomicron Metabolism
- Chylomicrons transport the dietry lipid from intestine to liver.
- Function of chylomicrons is to transport exogenous triglyceride to adipose tissue (for storage).
- Step I- Formation of Nascent Chylomicron- contains triglyceride, cholestryl ester, cholesterol, lipid, apo B-48 & apo A.
- Step II- Formation of Mature Chylomicron- by receiving apo C-II and apo E from HDL.
- Step III- Formation of Remanant Chylomicron– Apo C-II activates Lipoprotein Lipase
- Step IV- Uptake of Remnant Chylomicron
- Chylomicron remnant is taken up by the liver.
- Uptake is mediated by apo E via two apo E dependent recptors, LDL receptor and LDL receptor related protein-I (LRP-I).
Exam Important
- Chylomicrons transport the dietry lipid from intestine to liver.
- Function of chylomicrons is to transport exogenous triglyceride to adipose tissue (for storage).
- Step I- Formation of Nascent Chylomicron
- Step II- Formation of Mature Chylomicron- by receiving apo C-II and apo E from HDL.
- Step III- Formation of Remanant Chylomicron- Apo C-II activates Lipoprotein Lipase
- Step IV- Uptake of Remnant Chylomicron-
- Chylomicron remnant is taken up by the liver.
- Uptake is mediated by apo E via two apo E dependent recptors, LDL receptor and LDL receptor related protein-I (LRP-I).
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