Non Hodgkin Lymphoma

Non Hodgkin’s Lymphoma

Q. 1

Which of the following differentiates Hodgkin’s lymphoma from non Hodgkin’s lymphoma?

 A

Fever, night sweat, weight loss

 B

Generalized lymphadenopathy

 C

Elderly

 D

Reed stern berg cells

Q. 1

Which of the following differentiates Hodgkin’s lymphoma from non Hodgkin’s lymphoma?

 A

Fever, night sweat, weight loss

 B

Generalized lymphadenopathy

 C

Elderly

 D

Reed stern berg cells

Ans. D

Explanation:

In classic Hodgkin lymphoma, the neoplastic cell is the Reed-Sternberg (RS) cell. Reed-Sternberg cells comprise only 1-2% of the total tumor cell mass. Most Reed-Sternberg cells are of B-cell origin. The Reed-Sternberg cells consistently express the CD30 (Ki-1) and CD15 (Leu-M1) antigens.

Age-specific incidence rates of Hodgkin lymphoma and non-Hodgkin lymphoma have a bimodal distribution in both sexes, peaking in young adults (aged 15-34 y) and older individuals (>55 y). Asymptomatic lymphadenopathy may be present in both. Constitutional symptoms (eg, unexplained weight loss, fever, night sweats) are present in 40% of patients.


Q. 2

Non Hodgkin’s lymphoma —— diffuse,large cell type——– belongs to –

 A

Low grade

 B

Intermediate grade

 C

High grade

 D

None of the above

Q. 2

Non Hodgkin’s lymphoma —— diffuse,large cell type——– belongs to –

 A

Low grade

 B

Intermediate grade

 C

High grade

 D

None of the above

Ans. B

Explanation:

Ans. is ‘b’ i.e., Intermediate grade


Q. 3

‘Intermediate form’ of Non hodgkin’s lymphoma is :

 A

Small non cleaved cell

 B

Diffuse, small cleaved cell

 C

Lymphoblastic

 D

Large cell immunoblastic

Q. 3

‘Intermediate form’ of Non hodgkin’s lymphoma is :

 A

Small non cleaved cell

 B

Diffuse, small cleaved cell

 C

Lymphoblastic

 D

Large cell immunoblastic

Ans. B

Explanation:

Answer is B (Diffuse, small cleaved cell):

Working formulation of NHL for clinical usage is as follows:

Low grade

  1. Small lymphocytic Q
  2. Follicular, predominantly small cleaved cell Q
  3. Follicular, mixed, small cleaved and large cell. Q

Intermediate grade

  1. Follicular predominantly large cell Q
  2. Diffuse small cleaved cell
  3. Diffuse mixed small and large cell.
  4. Diffuse large cell.

High grade

  1. Large cell immunoblastic Q
  2. Lymphoblastic Q
  3. Small non cleaved cell.

Note that all varieties of diffuse fall in the intermediate grade category only.

Quiz In Between



Leave a Reply

Free Mini Course on Stomach

Mini Course – Stomach

22 High Yield Topics in Stomach

in Just 2 Hours

Submission received, thank you!

Close Window
%d bloggers like this:
Malcare WordPress Security