Non Hodgkin’s Lymphoma
Which of the following differentiates Hodgkin’s lymphoma from non Hodgkin’s lymphoma?
| A |
Fever, night sweat, weight loss |
|
| B |
Generalized lymphadenopathy |
|
| C |
Elderly |
|
| D |
Reed stern berg cells |
Which of the following differentiates Hodgkin’s lymphoma from non Hodgkin’s lymphoma?
| A |
Fever, night sweat, weight loss |
|
| B |
Generalized lymphadenopathy |
|
| C |
Elderly |
|
| D |
Reed stern berg cells |
In classic Hodgkin lymphoma, the neoplastic cell is the Reed-Sternberg (RS) cell. Reed-Sternberg cells comprise only 1-2% of the total tumor cell mass. Most Reed-Sternberg cells are of B-cell origin. The Reed-Sternberg cells consistently express the CD30 (Ki-1) and CD15 (Leu-M1) antigens.
Age-specific incidence rates of Hodgkin lymphoma and non-Hodgkin lymphoma have a bimodal distribution in both sexes, peaking in young adults (aged 15-34 y) and older individuals (>55 y). Asymptomatic lymphadenopathy may be present in both. Constitutional symptoms (eg, unexplained weight loss, fever, night sweats) are present in 40% of patients.
Non Hodgkin’s lymphoma —— diffuse,large cell type——– belongs to –
| A |
Low grade |
|
| B |
Intermediate grade |
|
| C |
High grade |
|
| D |
None of the above |
Non Hodgkin’s lymphoma —— diffuse,large cell type——– belongs to –
| A |
Low grade |
|
| B |
Intermediate grade |
|
| C |
High grade |
|
| D |
None of the above |
Ans. is ‘b’ i.e., Intermediate grade
‘Intermediate form’ of Non hodgkin’s lymphoma is :
| A |
Small non cleaved cell |
|
| B |
Diffuse, small cleaved cell |
|
| C |
Lymphoblastic |
|
| D |
Large cell immunoblastic |
‘Intermediate form’ of Non hodgkin’s lymphoma is :
| A |
Small non cleaved cell |
|
| B |
Diffuse, small cleaved cell |
|
| C |
Lymphoblastic |
|
| D |
Large cell immunoblastic |
Answer is B (Diffuse, small cleaved cell):
Working formulation of NHL for clinical usage is as follows:
Low grade
- Small lymphocytic Q
- Follicular, predominantly small cleaved cell Q
- Follicular, mixed, small cleaved and large cell. Q
Intermediate grade
- Follicular predominantly large cell Q
- Diffuse small cleaved cell
- Diffuse mixed small and large cell.
- Diffuse large cell.
High grade
- Large cell immunoblastic Q
- Lymphoblastic Q
- Small non cleaved cell.
Note that all varieties of diffuse fall in the intermediate grade category only.
