Amoxicillin

Amoxicillin

Q. 1 Drug not used in H. pylori :
 A

Metronidazole

 B

Omeprezole

 C

Mosapride

 D Amoxicillin
Q. 1 Drug not used in H. pylori :
 A

Metronidazole

 B

Omeprezole

 C

Mosapride

 D Amoxicillin
Ans. C

Explanation:

Mosapride[Ref. Harrison 16th/e p 888]

RECOMMENDED TREATMENT REGIMEN FOR HELICOBACTER PYLORI :

Regimen duration

Drug 1

Drug 2

Drug 3

Drug 4

1st line treatment

 

 

 

 

Regimen 1

OCA (7 days)

Omeprazole

Clarithromycin

Amoxicillin

 

Regimen 2

OCM (2 days)

Omeprazole

Clarithromycin

Metronidazole

 

2nd line treatment

 

 

 

 

Regimen 3

OBTM (14 days)

Omeprazole

Bismuth

Tetracycline

Metronidazole



Q. 2

The MOST frequently implicated antibiotic among the causes of DILI is:

 A

Amoxicillin -clavulanic acid

 B

Oxacillin

 C

Erythromycin

 D

Doxycyclin

Q. 2

The MOST frequently implicated antibiotic among the causes of DILI is:

 A

Amoxicillin -clavulanic acid

 B

Oxacillin

 C

Erythromycin

 D

Doxycyclin

Ans. A

Explanation:

Amoxicillin-clavulanic acid causes inflammatory cholestasis. It is the most common cause of antibiotic induced DILI.

Other examples of drugs causing Inflammatory cholestasis are

  • Phenothiazine
  • Oxacillin
  • Erythromycin oleate

 

Ref: Harrison, Edition-18, Page 2561


Q. 3

The most frequently implicated antibiotic among the causes of drug induced liver injury is:

 A

Tetracycline

 B

Amoxicillin-clavulanic acid

 C

Erythromycin

 D

Nalidixic acid

Q. 3

The most frequently implicated antibiotic among the causes of drug induced liver injury is:

 A

Tetracycline

 B

Amoxicillin-clavulanic acid

 C

Erythromycin

 D

Nalidixic acid

Ans. B

Explanation:

Amoxicillin-clavulanic acid : The most frequently implicated antibiotic among cases of drug-induced liver injury.


Reference:
Harrisons Principles of Internal Medicine, 18th Edition, Page 2560

Q. 4

A patient of Acute lymphocytic leukemia with fever and neutropenia develops diarrhoea after administration of amoxicillin therapy, which of the following organism is most likely to be the causativeagent –

 A

Salmonella typhi

 B

Clostridium difficile

 C

Clostridium perfringens 

 D

Shigella flexneri

Q. 4

A patient of Acute lymphocytic leukemia with fever and neutropenia develops diarrhoea after administration of amoxicillin therapy, which of the following organism is most likely to be the causativeagent –

 A

Salmonella typhi

 B

Clostridium difficile

 C

Clostridium perfringens 

 D

Shigella flexneri

Ans. B

Explanation:

Ans. is ‘b’ i.e., Clostridium difficile 


Q. 5

Drug of choice for prevention of infection by animal bite ‑

 A

Amoxicillin/clavulanate

 B

Tetracycline

 C

Ciprofloxacin

 D

Cotrimazole

Q. 5

Drug of choice for prevention of infection by animal bite ‑

 A

Amoxicillin/clavulanate

 B

Tetracycline

 C

Ciprofloxacin

 D

Cotrimazole

Ans. A

Explanation:

Ans. is ‘a’ i.e., Amoxicillin/clavulanate


Q. 6

Moraxella catarrhalis is resistant to which antibiotic‑

 A

Amoxicillin

 B

Clarithromycin

 C

Azithromycin

 D

Amoxicillin and clavulanic acid combination

Q. 6

Moraxella catarrhalis is resistant to which antibiotic‑

 A

Amoxicillin

 B

Clarithromycin

 C

Azithromycin

 D

Amoxicillin and clavulanic acid combination

Ans. A

Explanation:

Ans. is ‘a’ i.e., Amoxicillin

Treatment of M. caterrahlis infection:

M. catarrhalisrapidly acquired -lactamases during the 1970s and 1980s; antimicrobial susceptibility patterns have remained relatively stable since that time, with >90% of strains now producing -lactamase and thus resistant to amoxicillin.

Most strains of M. catarrhalisare susceptible to amoxicillin and clavulanic acid combination, extended-spectrum cephalosporins, newer macrolides (azithromycin, clarithromycin), trimethoprim- sulfamethoxazole, and fluoroquinolones.


Q. 7

Advantages of amoxicillin over ampicillin are all except‑

 A

Better bioavailability & faster action

 B

Spectrum includes H. influenzae & Shigella

 C

Incidence of diarrhea is lower

 D

Food does not interfere with its absorption

Q. 7

Advantages of amoxicillin over ampicillin are all except‑

 A

Better bioavailability & faster action

 B

Spectrum includes H. influenzae & Shigella

 C

Incidence of diarrhea is lower

 D

Food does not interfere with its absorption

Ans. B

Explanation:

Ans. is ‘b’ i.e., Spectrum includes H. influenzae & Shigella 



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